|
Iron deficiency anemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The optimal hepcidin cutoff for the diagnosis of corrected IDA based on maximal sensitivity and specificity was ≤1.6 µg/L.
|
31624364 |
2019 |
|
Iron deficiency anemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We studied the contribution of hepcidin-mediated iron blockade to IDA in African children.
|
30944864 |
2019 |
|
Iron deficiency anemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, mild acute inflammation did not increase serum hepcidin in women with IDA, suggesting low iron status and erythropoietic drive offset the inflammatory stimulus on hepcidin expression.
|
30630976 |
2019 |
|
Iron deficiency anemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
ESRD patients had significantly higher ferritin and hepcidin-25 (<0.001) relative to IDA patients.
|
30984307 |
2019 |
|
Iron deficiency anemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, urinary hepcidin holds promise as a noninvasive diagnostic tool for IDA in under-5 children.
|
30334902 |
2019 |
|
Iron deficiency anemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Conclusions:</b> This study suggests that serum hepcidin is superior to hemoglobin, serum iron, serum ferritin, TS, and TIBC as an indicator of IDA in pregnant women.
|
31220970 |
2019 |
|
Iron deficiency anemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The studies in the patients with iron deficiency anemia (IDA) implied the existence of the association of ghrelin with iron or hepcidin levels in the plasma under the pathophysiological conditions.
|
29241202 |
2018 |
|
Iron deficiency anemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our study suggests that hepcidin levels do not contribute to the development of iron deficiency anemia in pediatric obese individuals.
|
29318945 |
2018 |
|
Iron deficiency anemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Children and women with iron deficiency anemia had higher zinc-protoporphyrin/heme ratios (children=151 μmol/mol heme and women=155 μmol/mol heme) and lower hepcidin levels (children=1.2ng/mL and women=0.6ng/mL).
|
30093400 |
2018 |
|
Iron deficiency anemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We did not find markedly hepcidin levels in IDA patients compared to controls (P = 0.32).
|
29928945 |
2018 |
|
Iron deficiency anemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In iron deficiency anemia patients, serum erythroferrone concentrations correlated negatively with hemoglobin concentration (r = -.39; P = .01), serum iron (r = -.63; P < .001), transferrin saturation (r = -.66; P < .001), and serum ferritin (r = -.46; P = .004) while positive correlation was observed between serum erythroferrone concentrations and TIBC (r = .62; P < .001) CONCLUSION: The newly identified erythroferrone hormone may act as physiological hepcidin suppressor in cases with iron deficiency anemia, and so it may serve as a specific promising target of therapy in such cases.
|
29282766 |
2018 |
|
Iron deficiency anemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The significant positive correlation between ghrelin and iron and hepcidin levels in the plasma of children with iron deficiency anemia prompted us to hypothesize that ghrelin may affect iron metabolism.
|
28338217 |
2018 |
|
Iron deficiency anemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further studies are needed to determine the impact of inflammation on ferritin, hepcidin and therapeutic strategy for IDA in CKD.
|
30150549 |
2018 |
|
Iron deficiency anemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The study aims were to evaluate 1) the contribution of AI and iron deficiency anemia (IDA) to newborn iron endowment, 2) hepcidin as a biomarker to distinguish AI from IDA among pregnant women, and 3) risk factors for specific etiologies of maternal anemia.
|
29546300 |
2018 |
|
Iron deficiency anemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent research regarding hepcidin as a central regulator of iron homeostasis is promising, but it has not been used yet for the routine diagnosis of iron deficiency anemia.
|
29094497 |
2018 |
|
Iron deficiency anemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study suggests a protective role of HFE in IDA CD patients and confirms the role of TMPRSS6 in predicting oral iron response modulating hepcidin action on iron absorption.
|
29194702 |
2018 |
|
Iron deficiency anemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Given that hepcidin decrease may improve intestinal iron absorption, these results warrant further investigation in a larger cohort and especially in patients with IDA.
|
30469412 |
2018 |
|
Iron deficiency anemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results obtained suggest that in obese children with sufficient iron intake, the altered ferroportin-hepcidin axis may occur without signs of iron deficiency or iron deficiency anemia.
|
30275363 |
2018 |
|
Iron deficiency anemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The research showed that the concentration of hepcidin is statistically lower in children (4.4 ng/mL) and adolescents (4.1 ng/mL) who suffer from iron deficiency anemia in comparison with the control group (14 ng/mL, 10 ng/mL, respectively).
|
30584405 |
2018 |
|
Iron deficiency anemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Increased levels of hepcidin lead to reduced expression of intestinal ferroportin and mild iron deficiency anaemia.
|
29575577 |
2018 |
|
Iron deficiency anemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Tmprss6-mutated mask mice display iron deficiency anemia and high expression of hepcidin.
|
29073189 |
2017 |
|
Iron deficiency anemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Evaluation of a competitive hepcidin ELISA assay in the differential diagnosis of iron deficiency anaemia with concurrent inflammation and anaemia of inflammation in elderly patients.
|
28936123 |
2017 |
|
Iron deficiency anemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In ROC analysis, serum hepcidin and ferritin had similar moderate utility in differentiating iron deficiency anemia from anemia of chronic disorders (AUC 0.63 95% CI 0.47-0.79 and 0.76 95% CI 0.61-0.90, respectively).
|
25745821 |
2015 |
|
Iron deficiency anemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We found that Sox2 as a novel factor to bind with HAMP promoter to negatively regulate HAMP expression, which may be further implicated as a therapeutic option for the amelioration of HAMP-overexpression-related diseases, including iron deficiency anemia.
|
25943891 |
2015 |
|
Iron deficiency anemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Magnetic resonance imaging showed that iron overload was absent in nine patients, mild in one patient with metabolic syndrome, and high (180 μmol/g) in one patient with hereditary spherocytosis discovered after LT. At the end of follow-up, serum hepcidin was normal in 10 patients (11.12 ± 7.6 nmol/L; P<0.05) and low in one patient with iron deficiency anemia.
|
23775519 |
2014 |