|
Iron deficiency
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Our data demonstrate that elevated DNA methylation of the Hamp promoter region suppresses its expression, this epigenetic modification likely occurs in reaction to iron deficiency after bariatric surgery, helping to maintain system iron homeostasis.
|
31839527 |
2020 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
The discovery of hepcidin and its role in iron homeostasis has revolutionized our understanding of the pathogenesis of iron deficiency and iron overload states.
|
31830663 |
2020 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
A proposed new mechanism of exercise-induced iron deficiency in athletes involves the iron-regulatory hormone hepcidin, however, there is limited information on this amongst elite athletes.
|
31665878 |
2020 |
|
Iron deficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of hepcidin, the hormone regulating iron homeostasis, is increased by iron overload and decreased by accelerated erythropoiesis or iron deficiency.
|
30958854 |
2019 |
|
Iron deficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Infants of mothers with the lowest levels of circulating hepcidin during gestation, likely a marker for iron deficiency, had higher sTfR:SF levels and lower hemoglobin levels, particularly at 12 months of age.
|
31129681 |
2019 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
The purpose of this manuscript is to summarize current standard tools for identifying iron deficiency in anemic patients; explore the tools and context for evaluating novel markers, such as hepcidin, erythroferrone, and markers of the iron restriction response; and assess available evidence for how their use could increase our understanding of health outcomes in clinically challenging cases.
|
31808893 |
2019 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Under physiologic conditions, hepcidin production is reduced by iron deficiency and erythropoietic drive to increase the iron supply when needed to support red blood cell production and other essential functions.
|
30401708 |
2019 |
|
Iron deficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results showed that split iron supplementation efficiently improved hematological status of piglets and attenuated the induction of hepcidin expression, which resulted in the recovery of piglets from iron deficiency and the increase of iron utilization.
|
31557572 |
2019 |
|
Iron deficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Serum hepcidin levels and CHr were assessed in 65 early phase CHC patients (20 nonanemic, 23 anemic nonbleeders, and 22 anemic bleeders), and 20 healthy controls; and were compared with the conventional indices of iron deficiency including mean corpuscular volume, mean corpuscular hemoglobin, red cell distribution width, serum iron, total iron binding capacity, transferrin saturation and ferritin.
|
31567713 |
2019 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Aberrantly increased hepcidin leads to systemic iron deficiency and/or iron restricted erythropoiesis.
|
30798811 |
2019 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
The study found a significant correlation between serum hepcidin and iron deficiency-related parameters with adjustment for study groups (<i>p</i><.01).
|
31220970 |
2019 |
|
Iron deficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In a cross-sectional study with 779 patients, we assessed the prognostic potential of the major haematopoietic regulators, hepcidin and erythropoietin, comparing their serum concentrations with respect to different anaemia types, inflammatory activity, anti-cytokine-specific treatment effects and iron deficiency (ID) indices.
|
30941747 |
2019 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Vitamin D₃ supplementation had no effect on hepcidin, ferritin, or inflammatory status suggesting no adjunctive value of vitamin D₃ in reducing rates of antenatal iron deficiency.
|
30669280 |
2019 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nerve growth factor-beta (NGF-β)-differentiated PC12 cells, used as a model of neuronal cells, were evaluated in terms of their viability and expression of ferroportin after inducing cellular iron overload with ferric ammonium citrate (FAC) or hepcidin, iron deficiency with deferoxamine (DFO), or hepcidin in combination with FAC or DFO.
|
30027341 |
2019 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
The stimulus to the synthesis of hepcidin due to <i>H. pylori</i> infection is greater than the iron deficiency stimulus.
|
31500264 |
2019 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
An hepcidin cutoff of <4.3 µg/L had a sensitivity of 95% for regression-corrected ID.
|
31624364 |
2019 |
|
Iron deficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These mothers often had mild iron deficiency and measurable hepcidin levels.
|
31005753 |
2019 |
|
Iron deficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Even if in iron-deficiency anemia hepatic hepcidin expression is strongly suppressed by iron deficiency and erythropoietic drive, the intake of oral iron supplements leads to an acute hepcidin increase for 24 hours.
|
31413088 |
2019 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study is aimed at investigating ID with conventional (ferritin, transferrin saturation [TSAT]) and new biomarkers (soluble transferrin receptor [sTfR], sTfR/log ferritin, reticulocyte hemoglobin content [CHr], hepcidin-25) in patients sub-grouped by the presence or absence of H. pylori infection.
|
31154451 |
2019 |
|
Iron deficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Adaptation to iron deficiency at the tissue level is controlled by iron regulatory proteins to increase iron uptake and retention; at the systemic level, suppression of the iron hormone hepcidin increases iron release to plasma by absorptive enterocytes and recycling macrophages.
|
30401704 |
2019 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Iron deficiency diagnosed according to low hepcidin was an independent predictor of one-year mortality (OR 1.51 (1.10-2.08)) as was high sTfR/log ferritin ratio (OR = 1.95 (1.27-3.00)), but low ferritin was not.
|
30463596 |
2018 |
|
Iron deficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Different hepcidin levels between children with newly diagnosed CD and UC suggest the distinct contribution of iron deficiency and/or systemic inflammation to anaemia and may help clinicians choose the best anti-anaemic treatment.
|
29923651 |
2018 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Insufficiently suppressed hepcidin given the degree of iron deficiency in PV patients strongly suggests that disordered iron metabolism is an important component of the pathobiology of PV.
|
30042411 |
2018 |
|
Iron deficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Although levels of the iron hormone hepcidin were rather affected by ID than by inflammation, they were not associated with the clinical course or mortality of PH subjects.
|
30161261 |
2018 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
The ability of baseline hepcidin measurement to highlight ID in elderly anaemic patients was assessed using a receiver operator curve (ROC) analysis.
|
30055098 |
2018 |