Liver carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These animals showed an inverse association of the severity of HCC with bioactive hepcidin levels, which was significantly correlated with the hepatic myeloperoxidase activity.
|
30774778 |
2019 |
Liver carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, the copy number of hepcidin mRNA variant was significantly higher in serum exosomes of hepatocellular carcinoma patients.
|
30798808 |
2019 |
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study sought to examine the functional role of hepcidin in hepatocellular carcinoma (HCC).
|
31052210 |
2019 |
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
By analysing RNA-seq data encoding TMPRSS6 isoforms and other proteins involved in hepcidin production, we uncovered significant differences in expression levels between hepatocellular carcinoma (HCC) cell lines and normal human liver samples.
|
30135444 |
2018 |
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Gene expression and DNA methylation analyses on tissues showed that HAMP was transcriptionally repressed in HCC tissues consensually with a promoter hypermethylation.
|
29235098 |
2018 |
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
RGD |
Through a quantitative methylation analysis on HCC tissues, we then proved that methylation at definite CpG sites within consensus sequences for specific transcription factors is possibly the mechanism underlying HAMP repression.
|
29235098 |
2018 |
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
CTD_human |
Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling.
|
28284560 |
2017 |
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
By RT-PCR/agarose gel electrophoresis of hepcidin mRNA in a hepatocellular carcinoma cell line HLF, a smaller mRNA band was shown in addition to the wild-type hepcidin mRNA.
|
27264950 |
2016 |
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Previously, we reported that oxidative stress in male transgenic mice that expressed hepatitis C virus polyprotein (HCVTgM) caused hepatic iron accumulation by reducing hepcidin transcription, thereby leading to HCC development.
|
25156780 |
2015 |
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We analyzed human hepatoma (HepG2) cells and mouse primary hepatocytes to study transcriptional control of Hamp (the gene that encodes Hepcidin) in response to gluconeogenic stimuli using small interfering RNA, luciferase promoter, and chromatin immunoprecipitation analyses.
|
24361124 |
2014 |
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
We have measured secretion of hepcidin by primary macrophages and the hepatoma cell line HepG2 stimulated with IL-10, IL-6 and Plasmodium falciparum-infected erythrocytes.
|
24520384 |
2014 |
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
To address this issue, GFP was fused to the C-terminus of hepcidin and the chimeric hepcidin-GFP protein was expressed in hepatoma Huh7 cells.
|
23665013 |
2013 |
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In this study, we investigated the effect of changes in the pH of the microenvironment on hepcidin expression in human hepatoma and leukemia cell lines.
|
23179904 |
2012 |
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Alteration of hepcidin expression levels has been reported in the setting of chronic HCV infection and hepatocellular carcinoma.
|
23110054 |
2012 |
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
However and interestingly, hepcidin expression was reduced in HCC cell lines and tissues.
|
21863061 |
2011 |
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
However, in vitro studies with hepatoma cell lines often show an inverse relationship between iron status and hepcidin expression.
|
20576915 |
2010 |
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Hepcidin may play a role in defending the body against HCC.
|
19387685 |
2009 |
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
There was no significant correlation between hepcidin expression and the interval until HCC recurrence.
|
18541040 |
2008 |
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Hepcidin generated by hepatoma cells inhibits iron export from co-cultured THP1 monocytes.
|
16460831 |
2006 |
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this work, we characterized the effect of Hepc produced by hepatoma cells on iron absorption by intestinal cells.
|
16629180 |
2006 |
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Hepcidin expression was also measured in human hepatoma HepG2 cells following incubation with thalassemic sera.
|
16339657 |
2005 |