beta^+^ Thalassemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Correction of unbalanced iron absorption and recycling by induction of hepcidin synthesis or treatment with hepcidin mimetics ameliorates β-thalassemia.
|
31638596 |
2019 |
beta^+^ Thalassemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results support proposals that over-suppression of hepcidin seen in beta-thalassemia/Hb E patients is a consequence of the increased mass of erythropoiesis and not defects in the signaling process per se.
|
29157161 |
2018 |
beta^+^ Thalassemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Disturbances in the regulation of hepcidin contribute to the pathogenesis of many iron disorders: hepcidin deficiency causes iron overload in hereditary hemochromatosis and nontransfused β-thalassemia, whereas overproduction of hepcidin is associated with iron-restricted anemias seen in patients with chronic kidney disease, chronic inflammatory diseases, some cancers, and inherited iron-refractory iron deficiency anemia.
|
28096133 |
2017 |
beta^+^ Thalassemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hepcidin suppression in β-thalassemia is associated with the down-regulation of atonal homolog 8.
|
28405918 |
2017 |
beta^+^ Thalassemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent studies established that hypoxia and/or hypoxia-induced erythropoietin are not direct regulators of hepcidin, which is indirectly inhibited by erythropoietic drive, in particular under pathological conditions characterized by expanded but ineffective erythropoiesis, such as β-thalassemia.
|
28629515 |
2017 |
beta^+^ Thalassemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Insufficient hepcidin is implicated in parenchymal iron overload in β-thalassemia and approaches to increase hepcidin have therapeutic potential.
|
26635037 |
2016 |
beta^+^ Thalassemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dysregulation of hepcidin gives rise to disordered iron homeostasis, associated with diverse diseases including anemia and β-thalassemia.
|
25686467 |
2015 |
beta^+^ Thalassemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Hepcidin expression from monocyte of splenectomized and non-splenectomized patients with HbE-β-thalassemia.
|
23905873 |
2014 |
beta^+^ Thalassemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Misregulation of hepcidin is found in many disease states, such as the anemia of chronic disease, iron refractory iron deficiency anemia, cancer, hereditary hemochromatosis, and ineffective erythropoiesis, such as β-thalassemia.
|
23722909 |
2013 |
beta^+^ Thalassemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The goal of this paper is to review recent findings that correlate hepcidin, Hfe, and iron metabolism in beta-thalassemia and to discuss potential novel therapeutic approaches based on these recent discoveries.
|
20712796 |
2010 |
beta^+^ Thalassemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Hypertransfusional (>8 transfusions/year) iron in liver biopsies collected immediately after transfusions in beta-thalassemia and sickle cell disease correlated with increased expression (RNA) for iron regulatory proteins 1 and 2 (3-, 9- to 11-fold) and hepcidin RNA: (5- to 8-fold) (each p <.01), while ferritin H and L RNA remained constant.
|
17613866 |
2007 |
beta^+^ Thalassemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Urinary hepcidin levels in beta-thalassemia demonstrate severe hepcidin deficiency in thalassemia intermedia.
|
17488680 |
2007 |
beta^+^ Thalassemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In a mouse model of beta-thalassaemia, we observed that the liver expressed relatively low levels of hepcidin, which is a key factor in the regulation of iron absorption by the gut and of iron recycling by the reticuloendothelial system.
|
16939499 |
2006 |
beta^+^ Thalassemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We found decreased expression of hepcidin and TfR2 and increased expression of TfR1 and NGAL in the beta-thalassemia mouse models, compared with the control mice.
|
16755567 |
2006 |
beta^+^ Thalassemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study is to investigate Hamp in the mouse model of beta-thalassemia and to address the potential gene transfer of Hamp to prevent abnormal iron absorption.
|
16339690 |
2005 |