|
Chronic Lymphocytic Leukemia
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The RPPA investigation and its validation, identified 3 series of proteins: 1) molecules whose expression levels reached statistically significant differences in CLL vs. healthy controls (HSP70, Smac/DIABLO, cleaved PARP, and cleaved caspase-6); 2) proteins with a positive trend of difference in CLL vs. healthy controls (HS1, γ-tubulin, PKC α/β-II Thr-638/641, p38 MAPK Thr-180/Tyr-182, NF-κB Ser-536, Bcl2 Ser-70 and Src Tyr-527); and 3) molecules differentially expressed in patients with IGHV mutations vs. those without mutations (ZAP70, PKC-ζλ, Thr-410/403, and CD45).
|
27312846 |
2016 |
|
Chronic Lymphocytic Leukemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
In contrast to nontransgenic littermates, such animals had B-cell-restricted expression of ROR1 and could develop clonal expansions of ROR1(bright)CD5(+)B220(low) B cells resembling human CLL at ≥ 15 mo of age.
|
24379361 |
2014 |
|
Chronic Lymphocytic Leukemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
APRIL significantly prolonged in vitro survival of CD5(+)B220(dull) leukemic cells derived from the murine Eμ-TCL1-Tg (TCL1-Tg [transgenic]) model for CLL.
|
24100449 |
2013 |
|
Chronic Lymphocytic Leukemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
Flow cytometric enumeration was performed on 20 samples with CLL-like B cells and 10 control specimens using single platform (SP) and two DP tubes A: kappa, lambda, CD5, CD10, CD19, CD38, CD45, CD20 and B: FMC-7, CD23, CD19, CD5, with and without racking to remove doublets.
|
23475845 |
2013 |
|
Chronic Lymphocytic Leukemia
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
CD45 expression was markedly decreased for all patients with CLL with high percentages of smudge cells.
|
23733486 |
2013 |
|
Chronic Lymphocytic Leukemia
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Neither analysis of the T-cell receptor repertoire nor CD45 isoform expression of T(reg) cells from patients with CLL provided evidence for chronic (tumor) antigenic stimulation as a possible cause for T(reg) cells expansion in CLL.
|
19452318 |
2009 |
|
Chronic Lymphocytic Leukemia
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Class comparison analysis by significance analysis of microarrays on a subset of CLL samples (n = 14) indicated that a number of cell surface receptor and adhesion related genes were under-expressed in the 11q22.3 deletion group (CD44, CD11a, PTPRC, CD79a, chemokine ligand 17 and chemokine receptor type 6).
|
16321852 |
2006 |
|
Chronic Lymphocytic Leukemia
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The role of these CD45 splicing variants in the pathogenesis of CLL deserves further investigation.
|
12631259 |
2003 |
|
Chronic Lymphocytic Leukemia
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
CD45 isoform expression was studied in 204 cases of B-cell lymphoproliferative disease, including 162 chronic lymphocytic leukaemia (CLL).
|
7680734 |
1993 |