|
Lymphoma
|
0.090 |
Biomarker
|
group |
BEFREE |
Following a broad panel of immunohistochemical stains, the strong positive staining of the spindle cells for LCA (CD45), CD20, and Bcl-6 confirmed the diagnosis of follicle center cell lymphoma.
|
31693188 |
2020 |
|
Lymphoma
|
0.090 |
Biomarker
|
group |
BEFREE |
We evaluated CD45 as a therapeutic target for an antibody-radionuclide conjugate (ARC) for the treatment of lymphoma based on its ubiquitous expression, infrequent antigen loss or blockade, and the ability to target minimal disease based on panhematopoietic expression.
|
31481510 |
2019 |
|
Lymphoma
|
0.090 |
Biomarker
|
group |
BEFREE |
All cases were also positive for leukocyte common antigen contributing to the diagnostic confusion with lymphoma.
|
29237964 |
2018 |
|
Lymphoma
|
0.090 |
Biomarker
|
group |
BEFREE |
DPP8 and DPP9 expression were measured in mouse splenic CD4⁺ T-cells, CD8⁺ T-cells and B-cells (B220⁺), human lymphoma cell lines and mouse splenocytes stimulated with pokeweed mitogen (PWM) or lipopolysaccharide (LPS), and in dithiothreitol (DTT) and mitomycin-C treated Raji cells.
|
23704821 |
2013 |
|
Lymphoma
|
0.090 |
Biomarker
|
group |
BEFREE |
Accordingly, by combining in vitro and in vivo studies of human BL-xenografts grown in immunodeficient RAG2(-/-)γc(-/-) mice and of murine B220(+)IgM(+) B-cell lymphomas generated in Eμ-MYC and Eμ-MYC-BIM(+/-) transgenes, we demonstrate that lymphoma chemoresistance is dictated by BIM gene dosage and is reversible on BIM reactivation by genetic manipulation or after treatment with histone-deacetylase inhibitors.
|
20570860 |
2010 |
|
Lymphoma
|
0.090 |
Biomarker
|
group |
BEFREE |
Distinction of intraosseous lymphoblastic lymphoma from ES may be difficult because lymphomas may occasionally exhibit unexpected morphologic and immunophenotypic properties including LCA, CD3 and CD20 negativity and cytokeratin positivity.
|
11706081 |
2001 |
|
Lymphoma
|
0.090 |
AlteredExpression
|
group |
BEFREE |
In addition, these lymphomas occurred in men (15/15), frequently but not exclusively in association with HIV infection (13/15), in which homosexuality was a risk factor (13/13), presented initially as a lymphomatous effusion (14/15), remained localized to the body cavity of origin (13/15), expressed CD45 (15/15) and one or more activation-associated antigens (9/10) in the frequent absence of B-cell-associated antigens (11/15), exhibited clonal immunoglobulin gene rearrangements (13/13), contained Epstein-Barr virus (14/15), and lacked bcl-2, bcl-6, ras and p53 gene alterations (13/15).
|
8695812 |
1996 |
|
Lymphoma
|
0.090 |
GeneticVariation
|
group |
BEFREE |
We describe a case of a 73-year-old man who had cutaneous large cell lymphoma in the right leg (immunophenotype CD45+, CD19+, CD20+ CD22+, lambda clonal, cytokeratin-, NSE-) and lymphoma in left leg simulating Merkel cell carcinoma showing absence of leukocyte antigens (CD45-, CD20-, no light chains) and focal expression of keratin and NSE.
|
8539236 |
1995 |
|
Lymphoma
|
0.090 |
GeneticVariation
|
group |
BEFREE |
The LCALs had a more varied immunophenotype, with CD45 present only in 11 of 18 cases and keratin present in 5 of 18 of these rare lymphomas.
|
1711289 |
1991 |