Compared with the normal group, expressions of miR-365 and Bax were increased, and expressions of IGF-1 and Bcl-2 were decreased, with more apoptotic cells in diabetes mellitus rat models.
Furthermore, data indicated that subcellular localization of GAD had an effect on both the number and function of antigen presenting cells (APCs) recruited by BAX as well as on IFN-gamma secretion, and that diabetes suppression was unlikely to be caused by increased T helper 2 (Th2)-like activity.
The expression of two genes, BCL2, which inhibits apoptosis, and BAX, which induces apoptosis, was examined and correlated to the presence of risk factors that included hypertension, smoking, hyperlipidemia, and diabetes mellitus.