|
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Recent evidences also highlighted the importance of neuroglobin (Ngb) in ameliorating AD.
|
30300695 |
2019 |
|
Alzheimer's Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
To date, neuroglobin levels have been positively correlated with a beneficial outcome in a plethora of neurotoxic insults, e.g., ischemic and traumatic brain injuries and Alzheimer's disease.
|
29992530 |
2019 |
|
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Neuroglobin (Ngb) is a REST/NRSF-regulated protein, active in reactive oxygen species detoxification and cytochrome c inhibition, which provides a beneficial outcome in pathologies as Alzheimer's disease and strokes.
|
31158439 |
2019 |
|
Alzheimer's Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
These experimental findings suggest that upregulation of endogenous Ngb expression might be an effective intervention approach for AD.
|
30010125 |
2018 |
|
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Studies suggest that NGB exerts protective effects to neuronal cells and is implicated in reducing the severity of stroke and Alzheimer's disease.
|
27651453 |
2017 |
|
Alzheimer's Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Moreover, Ngb overexpression protects neurons from mitochondrial dysfunctions and neurodegenerative disorders such as Alzheimer disease; however, it facilitates the survival of cancer cells.
|
28707399 |
2017 |
|
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Although neuroglobin confers neuroprotection against Alzheimer's disease (AD) pathology, its expression becomes downregulated in late-stage AD.
|
28391636 |
2017 |
|
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our data indicate the anti-apoptotic property of Ngb may play a neuroprotective role against AD.
|
26346601 |
2016 |
|
Alzheimer's Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We found that a microRNA expressed with the NGB transcript shows significant target enrichments in the angiogenesis pathway and the Alzheimer disease/presenilin pathway.
|
24362753 |
2014 |
|
Alzheimer's Disease
|
0.300 |
Therapeutic
|
disease |
RGD |
This evidence reveals that IBU-LA administration has the capability to maintain a high Ngb level allowing Ngb to perform a neuroprotective and antiapoptotic role, representing a valid tool in the therapeutic strategy of AD progression.
|
23428737 |
2013 |
|
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our and others' data strongly support the involvement of NGB in AD.
|
19010568 |
2010 |
|
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Neuroglobin is found in high concentration in some neurons, and its high expression has been shown to promote survival of neurons in vitro and to protect brain from damage by both stroke and Alzheimer's disease in vivo.
|
20640154 |
2010 |
|
Alzheimer's Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Ngb may protect neurons from NMDA and Abeta toxicity by inhibiting the formation of a death-signaling membrane complex, and interventions that increase Ngb expression could have therapeutic application in AD and other neurodegenerative disorders.
|
18025470 |
2007 |
|
Heredodegenerative Disorders, Nervous System
|
0.300 |
Biomarker
|
group |
CTD_human |
p53-mediated apoptosis, neuroglobin overexpression, and globin deposits in a patient with hereditary ferritinopathy.
|
16825958 |
2006 |
|
Subarachnoid Hemorrhage
|
0.220 |
AlteredExpression
|
disease |
BEFREE |
We found that Ngb expressions were up regulated in the transcript and protein levels in a similar time dependent manner after SAH as compared to the sham group.
|
28774717 |
2018 |
|
Subarachnoid Hemorrhage
|
0.220 |
Biomarker
|
disease |
BEFREE |
Neuroglobin as a Novel Biomarker for Predicting Poor Outcomes in Aneurysmal Subarachnoid Hemorrhage.
|
29738858 |
2018 |
|
Subarachnoid Hemorrhage
|
0.220 |
Biomarker
|
disease |
RGD |
Expression and cell distribution of neuroglobin in the brain tissue after experimental subarachnoid hemorrhage in rats: a pilot study.
|
24281943 |
2014 |
|
Sleep Deprivation
|
0.200 |
Biomarker
|
phenotype |
RGD |
Sleep deprivation reduces neuroglobin immunoreactivity in the rat brain.
|
23262504 |
2013 |
|
Transient Ischemic Attack
|
0.200 |
Therapeutic
|
disease |
RGD |
[Involvement of cerebral neuroglobin in electroacupuncture preconditioning-induced protection effect in cerebral ischemia-reperfusion rats].
|
23342777 |
2012 |
|
Retinal ischemia
|
0.200 |
Biomarker
|
disease |
RGD |
Expression of neuroglobin in ocular hypertension induced acute hypoxic-ischemic retinal injury in rats.
|
22553688 |
2011 |
|
Encephalitis
|
0.200 |
Biomarker
|
disease |
RGD |
[Expression of neuroglobin in rats with brain injury induced by LPS].
|
19842562 |
2009 |
|
Transient Ischemic Attack
|
0.200 |
Biomarker
|
disease |
RGD |
Does neuroglobin protect neurons from ischemic insult? A quantitative investigation of neuroglobin expression following transient MCAo in spontaneously hypertensive rats.
|
16647691 |
2006 |
|
Transient Ischemic Attack
|
0.200 |
Biomarker
|
disease |
RGD |
Neuroglobin protects the brain from experimental stroke in vivo.
|
12621155 |
2003 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Altogether, reported results open new insights on the NGB effect in regulating intracellular pathways related to cell adaptive response to stress and, as consequence, to cell survival, beyond its direct effect as ROS scavenger, opening new prospective in cancer therapeutic intervention.
|
31686530 |
2020 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
In this review, the involvement of NGB in the cancer cell adaptation and resistance to oxidative stress will be discussed highlighting the globin role in the regulation of both the stress-induced apoptotic pathway and antioxidant systems activated by cancer cells.
|
31354909 |
2019 |