PVALB, parvalbumin, 5816

N. diseases: 148; N. variants: 0
Disease: Autistic Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.050 Biomarker disease BEFREE Our results suggest that restoring PV interneuron function in the mPFC may be a novel and effective treatment strategy to reduce the core symptoms of autism. 29453447 2018
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.050 Biomarker disease BEFREE We show that the number of parvalbumin+ interneurons in these 3 cortical areas-BA46, BA47, and BA9-is significantly reduced in autism compared with controls. 26922658 2017
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.050 AlteredExpression disease BEFREE We report that parvalbumin expression is depressed in Purkinje cells of the cerebellum in autism. 28707805 2017
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.050 AlteredExpression disease BEFREE Reduced expression of parvalbumin, a marker of mature FS cells, has been reported in individuals with schizophrenia and bipolar disorder and in mouse models of schizophrenia and autism. 22936973 2012
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.050 Biomarker disease BEFREE Moreover, CAPS2(-/-) mice had fewer cortical and hippocampal parvalbumin-positive interneurons and some autistic-like behavioral phenotypes. 19238500 2009