PVALB, parvalbumin, 5816

N. diseases: 148; N. variants: 0
Disease: Impaired cognition ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 GeneticVariation disease BEFREE Cognitive deficits are strongly associated with the dysfunction of GABAergic parvalbumin interneurons (PV-IN). 31150746 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 Biomarker disease BEFREE Treatment with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl)urea (TPPU), a potent sEH inhibitor, in juvenile offspring from prenatal day (P) 28 to P56 could prevent cognitive deficits and loss of parvalbumin (PV) immunoreactivity in the medial PFC of adult offspring after MIA. 30890645 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 Biomarker disease BEFREE Here we demonstrate that adult LgDel<sup>+/-</sup> mice, a genetic model of schizophrenia, exhibit PV neuron hypo-recruitment and associated chronic PV neuron plasticity together with network and cognitive deficits. 31474363 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 Biomarker disease BEFREE Dysfunction of prefrontal parvalbumin (PV+) interneurons has been linked with severe cognitive deficits as observed in several neurodevelopmental disorders including schizophrenia. 30792384 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 Biomarker disease BEFREE The overexpression of NL1 can upregulate the expression levels of PV, Nrx1β and PSD95 in mice with POCD, enhance the interaction between NL1 and Nrx1β and further increase the excitability of PV interneurons, thus restoring the hippocampus-dependent memorial and cognitive impairment in POCD. 30936983 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 Biomarker disease BEFREE Developmental Ethanol-Induced Sleep Fragmentation, Behavioral Hyperactivity, Cognitive Impairment and Parvalbumin Cell Loss are Prevented by Lithium Co-treatment. 29183826 2018
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 Biomarker disease BEFREE TDP-43<sup>Q331K</sup> mice demonstrate cognitive dysfunction and a paucity of parvalbumin interneurons. 29556029 2018
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 Biomarker disease BEFREE Our findings reveal that neuropathic pain-related cognitive impairments in male mice are correlated to bilateral morphological changes in PV interneurons and layer 5/6 IL pyramidal neuron AIS. 30030404 2018
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 Biomarker disease BEFREE Here we demonstrated that dietary intake of glucoraphanin (GF), the precursor of a natural antioxidant sulforaphane, during juvenile and adolescent stages prevented cognitive deficits and loss of parvalbumin (PV) immunoreactivity in the medial prefrontal cortex (mPFC) of adult offspring after MIA. 29391571 2018
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 Biomarker disease BEFREE Based on prior investigations that environmental enrichment reverses impaired cognition after anesthetic exposure, we proposed that environmental enrichment protects PV interneurons and thereby improves sevoflurane-induced cognitive impairments. 27251428 2017
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 Biomarker disease BEFREE We hypothesized that disturbed neuregulin 1 (NRG1)-ErbB4 signaling in the parvalbumin interneurons was involved in sepsis-induced cognitive impairment in a mouse model of SAE. 27913953 2017
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 GeneticVariation disease BEFREE Substantial evidence suggests that abnormalities in inhibitory γ-aminobutyric acid (GABA) interneuron function, especially in the parvalbumin subtype of GABA interneuron, both developmentally and in adulthood, may contribute mechanistically to cognitive deficits and psychotic symptoms in schizophrenia. 28214898 2016
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 Biomarker disease BEFREE These findings reveal lower KCNS3 expression in prefrontal cortical parvalbumin neurons in schizophrenia, providing a molecular basis for compromised detection of coincident synaptic inputs to parvalbumin neurons that could contribute to altered γ-oscillations and impaired cognition in schizophrenia. 24170294 2014
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 Biomarker disease BEFREE The cognitive deficits of schizophrenia appear to be associated with altered cortical GABA neurotransmission in the subsets of inhibitory neurons that express either parvalbumin (PV) or somatostatin (SST). 22937123 2012
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 Biomarker disease BEFREE The findings that lower GAD67 mRNA expression is common in schizophrenia, that it is not a consequence of having the illness, and that it leads to less translation of the protein, especially in the axon terminals of parvalbumin-containing neurons, support the hypothesis that lower GABA synthesis in parvalbumin neurons contributes to dorsolateral prefrontal cortex dysfunction and impaired cognition in schizophrenia. 21632647 2011
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 Biomarker disease BEFREE Dysfunction of inhibitory neurons in the prefrontal cortex (PFC), represented by decreased expression of GABA-related genes such as the 67 kDa isoform of glutamate decarboxylase (GAD67) and parvalbumin (PV), appears to contribute to cognitive deficits in subjects with schizophrenia. 15647480 2005
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 AlteredExpression disease BEFREE Given the critical role that PV-containing GABA neurons appear to play in regulating the cognitive functions mediated by the PFC, the selective alterations in gene expression in these neurons may contribute to the cognitive deficits characteristic of schizophrenia. 12867516 2003