Malignant neoplasm of breast
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
Alcohol consumption
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
|
24376456 |
2013 |
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
|
24376456 |
2013 |
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
Malignant Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
The WFDC1 gene was mapped by FISH analysis to human Chromosome (Chr) 16q24, an area of frequent loss of heterozygosity (LOH) previously identified in multiple cancers including prostate, breast, hepatocellular, and Wilms' tumor.
|
10967136 |
2000 |
Nephroblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The WFDC1 gene was mapped by FISH analysis to human Chromosome (Chr) 16q24, an area of frequent loss of heterozygosity (LOH) previously identified in multiple cancers including prostate, breast, hepatocellular, and Wilms' tumor.
|
10967136 |
2000 |
Childhood Kidney Wilms Tumor
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The WFDC1 gene was mapped by FISH analysis to human Chromosome (Chr) 16q24, an area of frequent loss of heterozygosity (LOH) previously identified in multiple cancers including prostate, breast, hepatocellular, and Wilms' tumor.
|
10967136 |
2000 |
Liver carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The WFDC1 gene maps in human chromosome 16q24, an area of frequent loss of heterozygosity (LOH) in several tumour types, in particular in hepatocellular carcinoma (HCC).
|
12032731 |
2002 |
melanoma
|
0.310 |
Biomarker
|
disease |
CTD_human |
Epigenetic silencing of novel tumor suppressors in malignant melanoma.
|
17145863 |
2006 |
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Gene expression microarray analysis and further expression validation suggests that the Dickkopf-1 (Dkk1) gene is up-regulated in WFDC1 over-expressing cell lines, suggesting that the tumor suppressive function of WFDC1 may be partially a result of up-regulated Dkk1 gene expression, which is known to be a potent inhibitor of the Wnt signaling pathway.
|
19488830 |
2009 |
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
WFDC1/ps20 expression is frequently downregulated or lost in prostate cancer (PCa) and ps20 has demonstrated growth-suppressive functions in numerous tumour model systems, although the mechanisms of this phenomenon are not understood.
|
27115470 |
2016 |
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
To address the potential effects of ps20 in a tumor microenvironment, we used the DRS model to evaluate both angiogenesis and tumorigenesis of tumors generated under either ps20 or control conditions.
|
14522910 |
2003 |
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
We, therefore, propose that WFDC1/ps20 may not be a classical tumor suppressor gene, but might play a role in the maintenance of the normal extra cellular matrix milieu in the prostate.
|
15305342 |
2004 |
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
We further investigated the role of WFDC1 as a tumour suppressor gene candidate in five hepatocellular cell lines and in tumours exhibiting LOH by means of mutation, promoter methylation and gene expression analysis.
|
12032731 |
2002 |
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Taken together, our data suggest an important role for WFDC1 in inhibiting proliferation of both tumors and senescent cells.
|
18842679 |
2009 |
Malignant neoplasm of prostate
|
0.040 |
Biomarker
|
disease |
BEFREE |
Promotion of angiogenesis by ps20 in the differential reactive stroma prostate cancer xenograft model.
|
14522910 |
2003 |
Prostate carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Promotion of angiogenesis by ps20 in the differential reactive stroma prostate cancer xenograft model.
|
14522910 |
2003 |
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
To address the potential effects of ps20 in a tumor microenvironment, we used the DRS model to evaluate both angiogenesis and tumorigenesis of tumors generated under either ps20 or control conditions.
|
14522910 |
2003 |
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Identification and characterization of the WFDC1 gene may aid in better understanding the potential role of this gene and ps20 in prostate biology and carcinogenesis.
|
10967136 |
2000 |
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Mechanistic studies show that SORBS2 binds the 3' untranslated regions (UTRs) of WFDC1 (WAP four-disulfide core domain 1) and IL-17D (Interleukin-17D), two secreted molecules that are shown to act as metastasis suppressors.
|
29548303 |
2018 |
Cavitation
|
0.010 |
Biomarker
|
disease |
BEFREE |
Addition of PS20 to formulations in glass and silicone oil-coated glass vials significantly reduced both incidence of mechanical shock-induced cavitation, and the particle formation that resulted from cavitation events.
|
31758950 |
2020 |
Hepatocarcinogenesis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest a minor role, if any, of WFDC1 in hepatocarcinogenesis.
|
12032731 |
2002 |
Influenza A
|
0.010 |
Biomarker
|
disease |
BEFREE |
Wfdc1-null mice infected with influenza A exhibited 2.75-log-fold lower viral titer relative to control mice.
|
25219356 |
2014 |
melanoma
|
0.310 |
PosttranslationalModification
|
disease |
BEFREE |
Furthermore, we show that promoter hypermethylation accounts for the silencing of the WFDC1 gene in 20% of the melanoma cell lines examined.
|
19488830 |
2009 |
Malignant neoplasm of prostate
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
WPMY-1 stromal cells expressing ps20 were characterised by transcriptome microarray and the function of WPMY-1 conditioned media on growth of PCa cell lines was assessed.
|
27115470 |
2016 |