WFDC1, WAP four-disulfide core domain 1, 58189

N. diseases: 22; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.300 GeneticVariation disease UNIPROT
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.030 Biomarker phenotype BEFREE Identification and characterization of the WFDC1 gene may aid in better understanding the potential role of this gene and ps20 in prostate biology and carcinogenesis. 10967136 2000
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 GeneticVariation group BEFREE The WFDC1 gene was mapped by FISH analysis to human Chromosome (Chr) 16q24, an area of frequent loss of heterozygosity (LOH) previously identified in multiple cancers including prostate, breast, hepatocellular, and Wilms' tumor. 10967136 2000
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.010 GeneticVariation disease BEFREE The WFDC1 gene was mapped by FISH analysis to human Chromosome (Chr) 16q24, an area of frequent loss of heterozygosity (LOH) previously identified in multiple cancers including prostate, breast, hepatocellular, and Wilms' tumor. 10967136 2000
CUI: C1333015
Disease: Childhood Kidney Wilms Tumor
Childhood Kidney Wilms Tumor 		0.010 GeneticVariation disease BEFREE The WFDC1 gene was mapped by FISH analysis to human Chromosome (Chr) 16q24, an area of frequent loss of heterozygosity (LOH) previously identified in multiple cancers including prostate, breast, hepatocellular, and Wilms' tumor. 10967136 2000
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE We further investigated the role of WFDC1 as a tumour suppressor gene candidate in five hepatocellular cell lines and in tumours exhibiting LOH by means of mutation, promoter methylation and gene expression analysis. 12032731 2002
CUI: C1512409
Disease: Hepatocarcinogenesis
Hepatocarcinogenesis 		0.010 Biomarker disease BEFREE These results suggest a minor role, if any, of WFDC1 in hepatocarcinogenesis. 12032731 2002
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.010 GeneticVariation disease BEFREE The WFDC1 gene maps in human chromosome 16q24, an area of frequent loss of heterozygosity (LOH) in several tumour types, in particular in hepatocellular carcinoma (HCC). 12032731 2002
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE To address the potential effects of ps20 in a tumor microenvironment, we used the DRS model to evaluate both angiogenesis and tumorigenesis of tumors generated under either ps20 or control conditions. 14522910 2003
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.040 Biomarker disease BEFREE Promotion of angiogenesis by ps20 in the differential reactive stroma prostate cancer xenograft model. 14522910 2003
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.040 Biomarker disease BEFREE Promotion of angiogenesis by ps20 in the differential reactive stroma prostate cancer xenograft model. 14522910 2003
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.030 Biomarker phenotype BEFREE To address the potential effects of ps20 in a tumor microenvironment, we used the DRS model to evaluate both angiogenesis and tumorigenesis of tumors generated under either ps20 or control conditions. 14522910 2003
CUI: C0013261
Disease: Duane Retraction Syndrome
Duane Retraction Syndrome 		0.010 AlteredExpression disease BEFREE In addition, we show that ps20 mRNA synthesis is induced by TGF-beta1, a known regulator of endothelial cell-pericyte interactions and of stromal cell-induced angiogenesis in DRS tumors. 14522910 2003
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE We, therefore, propose that WFDC1/ps20 may not be a classical tumor suppressor gene, but might play a role in the maintenance of the normal extra cellular matrix milieu in the prostate. 15305342 2004
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.040 AlteredExpression disease BEFREE We, therefore, chose to examine WFDC1/ps20 for mutations and expression changes in prostate cancer. 15305342 2004
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.040 AlteredExpression disease BEFREE We, therefore, chose to examine WFDC1/ps20 for mutations and expression changes in prostate cancer. 15305342 2004
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.010 AlteredExpression group BEFREE Quantitative RT-PCR demonstrated significant down regulation of WFDC1/ps20 in prostate tumors. 15305342 2004
CUI: C0025202
Disease: melanoma
melanoma 		0.310 Biomarker disease CTD_human Epigenetic silencing of novel tumor suppressors in malignant melanoma. 17145863 2006
CUI: C0025202
Disease: melanoma
melanoma 		0.310 PosttranslationalModification disease BEFREE Furthermore, we show that promoter hypermethylation accounts for the silencing of the WFDC1 gene in 20% of the melanoma cell lines examined. 19488830 2009
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE Gene expression microarray analysis and further expression validation suggests that the Dickkopf-1 (Dkk1) gene is up-regulated in WFDC1 over-expressing cell lines, suggesting that the tumor suppressive function of WFDC1 may be partially a result of up-regulated Dkk1 gene expression, which is known to be a potent inhibitor of the Wnt signaling pathway. 19488830 2009
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE Taken together, our data suggest an important role for WFDC1 in inhibiting proliferation of both tumors and senescent cells. 18842679 2009
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.030 AlteredExpression phenotype BEFREE Modulated expression of WFDC1 during carcinogenesis and cellular senescence. 18842679 2009
CUI: C0016057
Disease: Fibrosarcoma
Fibrosarcoma 		0.010 AlteredExpression disease BEFREE Overexpression of WFDC1 inhibited the growth rate of the fibrosarcoma HT1080 cell line. 18842679 2009
CUI: C0278595
Disease: Adult Fibrosarcoma
Adult Fibrosarcoma 		0.010 AlteredExpression disease BEFREE Overexpression of WFDC1 inhibited the growth rate of the fibrosarcoma HT1080 cell line. 18842679 2009
CUI: C0001948
Disease: Alcohol consumption
Alcohol consumption 		0.100 GeneticVariation phenotype GWASCAT Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9. 24376456 2013