|
Alzheimer's Disease
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Shared genetic architecture between metabolic traits and Alzheimer's disease: a large-scale genome-wide cross-trait analysis.
|
30805717 |
2019 |
|
Alzheimer's Disease
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
|
30617256 |
2019 |
|
Alzheimer's Disease
|
0.440 |
GeneticVariation
|
disease |
BEFREE |
Here, we report the identification of AD causal variants in PVRL2 and APOC1 regions in proximity to APOE and define common risk haplotypes independent of APOE-ε4 coding change.
|
31346172 |
2019 |
|
Alzheimer's Disease
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.
|
30636644 |
2019 |
|
Alzheimer's Disease
|
0.440 |
Biomarker
|
disease |
BEFREE |
The altered regulation of PVRL2 may increase the susceptibility AD patients to HSV and other virus infections of the brain.
|
30319691 |
2018 |
|
Alzheimer's Disease
|
0.440 |
Biomarker
|
disease |
BEFREE |
To better understand the biological mechanisms underlying the regulation of AD biomarkers, and its relation to AD, we examined the association between 36 selected single nucleotide polymorphisms (SNPs) and AD biomarkers Aβ1-42, t-tau, and p-tau in CSF in a cohort of 672 samples (571 AD patients and 101 controls) collected within 10 European consortium centers.Our results highlighted five genes, APOE, LOC100129500, PVRL2, SNAR-I, and TOMM40, previously described as main players in the regulation of CSF biomarkers levels, further reinforcing a role for these in AD pathogenesis.
|
30320580 |
2018 |
|
Alzheimer's Disease
|
0.440 |
Biomarker
|
disease |
CTD_human |
The results of analyses confirmed strong associations of genetic variants from well-known genes APOE, TOMM40, PVRL2 (NECTIN2), and APOC1 with AD.
|
29107063 |
2018 |
|
Alzheimer's Disease
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |
|
Alzheimer's Disease
|
0.440 |
Biomarker
|
disease |
CTD_human |
To better understand the biological mechanisms underlying the regulation of AD biomarkers, and its relation to AD, we examined the association between 36 selected single nucleotide polymorphisms (SNPs) and AD biomarkers Aβ1-42, t-tau, and p-tau in CSF in a cohort of 672 samples (571 AD patients and 101 controls) collected within 10 European consortium centers.Our results highlighted five genes, APOE, LOC100129500, PVRL2, SNAR-I, and TOMM40, previously described as main players in the regulation of CSF biomarkers levels, further reinforcing a role for these in AD pathogenesis.
|
30320580 |
2018 |
|
Alzheimer's Disease
|
0.440 |
Biomarker
|
disease |
CTD_human |
The altered regulation of PVRL2 may increase the susceptibility AD patients to HSV and other virus infections of the brain.
|
30319691 |
2018 |
|
Alzheimer's Disease
|
0.440 |
Biomarker
|
disease |
BEFREE |
The results of analyses confirmed strong associations of genetic variants from well-known genes APOE, TOMM40, PVRL2 (NECTIN2), and APOC1 with AD.
|
29107063 |
2018 |
|
Alzheimer's Disease
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages.
|
29274321 |
2018 |
|
Alzheimer's Disease
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Transethnic genome-wide scan identifies novel Alzheimer's disease loci.
|
28183528 |
2017 |
|
Alzheimer's Disease
|
0.440 |
GeneticVariation
|
disease |
GWASDB |
Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies.
|
24755620 |
2014 |
|
Alzheimer's Disease
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study.
|
23419831 |
2014 |
|
Alzheimer's Disease
|
0.440 |
GeneticVariation
|
disease |
GWASDB |
SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.
|
23565137 |
2013 |
|
Alzheimer's Disease
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.
|
23565137 |
2013 |
|
Alzheimer's Disease
|
0.440 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of Alzheimer's disease with psychotic symptoms.
|
22005930 |
2012 |
|
Alzheimer's Disease
|
0.440 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association analysis of age-at-onset in Alzheimer's disease.
|
22005931 |
2012 |
|
Alzheimer's Disease
|
0.440 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of Alzheimer's disease.
|
22832961 |
2012 |
|
Alzheimer's Disease
|
0.440 |
GeneticVariation
|
disease |
GWASDB |
The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease.
|
21627779 |
2011 |
|
Alzheimer's Disease
|
0.440 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.
|
21379329 |
2011 |
|
Alzheimer's Disease
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
A comprehensive genetic association study of Alzheimer disease in African Americans.
|
22159054 |
2011 |
|
Alzheimer's Disease
|
0.440 |
GeneticVariation
|
disease |
GWASDB |
A comprehensive genetic association study of Alzheimer disease in African Americans.
|
22159054 |
2011 |
|
Alzheimer's Disease
|
0.440 |
GeneticVariation
|
disease |
GWASDB |
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
|
21460841 |
2011 |