|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling.
|
28284560 |
2017 |
|
Hepatitis, Toxic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.
|
16099942 |
2005 |
|
Drug-Induced Liver Disease
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.
|
16099942 |
2005 |
|
Hepatitis, Drug-Induced
|
0.300 |
Biomarker
|
disease |
CTD_human |
Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.
|
16099942 |
2005 |
|
Drug-Induced Acute Liver Injury
|
0.300 |
Biomarker
|
disease |
CTD_human |
Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.
|
16099942 |
2005 |
|
Chemical and Drug Induced Liver Injury
|
0.300 |
Biomarker
|
disease |
CTD_human |
Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.
|
16099942 |
2005 |
|
Chemically-Induced Liver Toxicity
|
0.300 |
Biomarker
|
disease |
CTD_human |
Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.
|
16099942 |
2005 |
|
Colorectal Carcinoma
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Smoking
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
GWAS and systems biology analysis of depressive symptoms among smokers from the COPDGene cohort.
|
30219690 |
2019 |
|
Major Depressive Disorder
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
GWAS and systems biology analysis of depressive symptoms among smokers from the COPDGene cohort.
|
30219690 |
2019 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Myopia
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Detection and interpretation of shared genetic influences on 42 human traits.
|
27182965 |
2016 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
We demonstrate that pregnancy zone protein (PZP), which is dramatically elevated in maternal plasma during pregnancy, efficiently inhibits in vitro the aggregation of misfolded proteins, including the amyloid beta peptide (Aβ) that is implicated in preeclampsia as well as with Alzheimer's disease.
|
30850528 |
2019 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our data link the finding of elevated serum PZP levels with the characteristic AD pathology and identify PZP as a novel component in AD.
|
25737043 |
2015 |
|
Bronchiectasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In a validation study of 124 patients, sputum but not serum concentrations of PZP were significantly associated with the Bronchiectasis Severity Index, the frequency of exacerbations, and symptoms.
|
31264895 |
2019 |
|
Malignant Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The stop-gain mutation (rs117889746) of the PZP gene in the BRONJ cancer group was significantly identified in the additive trend model analysis.
|
31747953 |
2019 |
|
Myocardial Infarction
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Area under the curve values used to diagnose early-onset MI for LRG and PZP are 0.939 and 0.874, respectively.
|
30411527 |
2019 |
|
West Nile Fever
|
0.010 |
Biomarker
|
disease |
BEFREE |
In comparison, no mortality was observed in DKO mice, suggesting that PZP and MUG-1 play a deleterious role in WNV infection.
|
30814992 |
2019 |
|
West Nile viral infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
Adult C57BL/6J wild-type and PZP/MUG-1 double knockout (DKO) mice were inoculated subcutaneously with WNV and mortality, virus burden, and immune responses were analyzed.
|
30814992 |
2019 |
|
Primary malignant neoplasm
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The stop-gain mutation (rs117889746) of the PZP gene in the BRONJ cancer group was significantly identified in the additive trend model analysis.
|
31747953 |
2019 |
|
Non-ST Elevated Myocardial Infarction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Several transcripts displayed suggestively higher (FBXL4, ECHDC3, KCNE1, TAOK2, AURKB, ERG, and FKBP5) and lower (MIAT, PVRL3, and PZP) expression in STEMI platelets compared to NSTEMI.
|
26367242 |
2016 |
|
Presenile dementia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Increased levels of pregnancy zone protein (PZP) were found in the serum of persons who later developed Alzheimer's disease (AD) in comparison to controls who remained dementia free.
|
25737043 |
2015 |
|
Senile Plaques
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the AD cortex, PZP immunoreactivity localized to microglial cells that interacted with senile plaques and was occasionally observed in neurons.
|
25737043 |
2015 |
|
Dementia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Increased levels of pregnancy zone protein (PZP) were found in the serum of persons who later developed Alzheimer's disease (AD) in comparison to controls who remained dementia free.
|
25737043 |
2015 |