RAC1, Rac family small GTPase 1, 5879

N. diseases: 415; N. variants: 20
Disease: Asbestosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003949
Disease: Asbestosis
Asbestosis 		0.010 Biomarker disease BEFREE This study shows that Rac1 is localized in the mitochondria of alveolar macrophages from asbestosis patients, and mitochondrial import requires the C-terminal cysteine of Rac1 (Cys-189), which is post-translationally modified by geranylgeranylation. 22157762 2012