RAC1, Rac family small GTPase 1, 5879

N. diseases: 415; N. variants: 20
Disease: Astrocytoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.040 AlteredExpression disease BEFREE In clinical samples, FilGAP expression was significantly increased in grade (G) II astrocytomas as compared to normal astrocytes, but its expression strongly decreased in a grade-dependent manner, and was positively associated with isocitrate dehydrogenase 1 (IDH1) mutations and inversely to cytoplasmic Rac1. 27790861 2016
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.040 AlteredExpression disease BEFREE Rab23 is overexpressed in human astrocytoma and promotes cell migration and invasion through regulation of Rac1. 26897750 2016
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.040 Biomarker disease BEFREE Our data show that Rac1 plays a major role in astrocytoma morphology, motility, and invasion. 16204049 2005
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.040 GeneticVariation disease BEFREE Three astrocytomas had rac1 gene mutation, including one grade II, one grade III, and one grade IV astrocytoma. 14736526 2004