RAC1, Rac family small GTPase 1, 5879

N. diseases: 415; N. variants: 20
Disease: Adult Fibrosarcoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0278595
Disease: Adult Fibrosarcoma
Adult Fibrosarcoma 		0.020 GeneticVariation disease BEFREE Sonication of xenograft HT1080 fibrosarcoma tumors released extracellular vesicles that contained detectable RAC1 mRNA with the highly tumorigenic N92I mutation known to exist in HT1080 cells. 27793845 2017
CUI: C0278595
Disease: Adult Fibrosarcoma
Adult Fibrosarcoma 		0.020 Biomarker disease BEFREE In this report, we provide evidence that Rac1, one member of Rho-related small GTPases, is a mediator of MMP-2 activation in HT1080 fibrosarcoma cells cultured in three-dimensional collagen gel (3D-col) and that MMP-2 activation is required for Rac1-promoted cell invasion through collagen barrier. 11340084 2001