melanoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Notably, Rac1 expression, and its interaction with Bcl-2, positively correlate with S70pBcl-2 levels in patient-derived lymphoma tissues and with advanced stage lymphoma and melanoma.
|
31103719 |
2019 |
melanoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
These data suggest a critical link between cell morphology and cell signaling and reconcile the dichotomy of Rac1's regulation of both proliferation and actin assembly by revealing a mutual signaling axis wherein actin assembly drives proliferation in melanoma.
|
31063759 |
2019 |
melanoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
RAC1 P29 is the third most commonly mutated codon in human cutaneous melanoma, after BRAF V600 and NRAS Q61.
|
31257073 |
2019 |
melanoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We also found and that RAC1-mutant human melanoma cells are resistant to clinical inhibitors of BRAF but are uniquely sensitive to PAK inhibitors.
|
29059171 |
2018 |
melanoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Recently, a self-activating mutation of Rac1, Rac1<sup>P29S</sup>, has been identified as a recurrent somatic mutation frequently found in sun-exposed melanomas, which possesses increased inherent GDP/GTP exchange activity and cell transforming ability.
|
29432733 |
2018 |
MENTAL RETARDATION, AUTOSOMAL DOMINANT 48
|
0.600 |
GeneticVariation
|
disease |
UNIPROT |
RAC1 Missense Mutations in Developmental Disorders with Diverse Phenotypes.
|
28886345 |
2017 |
MENTAL RETARDATION, AUTOSOMAL DOMINANT 48
|
0.600 |
GermlineCausalMutation
|
disease |
ORPHANET |
RAC1 Missense Mutations in Developmental Disorders with Diverse Phenotypes.
|
28886345 |
2017 |
melanoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study identifies an ERK-dependent mechanism that drives PREX1 upregulation and subsequent RAC1-dependent invasion in BRAF- and NRAS-mutant melanoma.
|
27418645 |
2016 |
melanoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A point mutation (P29S) in the RAS-related C3 botulinum toxin substrate 1 (RAC1) was considered to be a trigger for melanoma, a form of skin cancer with highest mortality rate.
|
27699663 |
2016 |
melanoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
RAC1 and melanoma.
|
25465943 |
2015 |
melanoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Induction of MDA-9/syntenin in melanoma was found to occur in a thrombin-independent signaling pathway and involves the PAR-1/c-Src/Rho GTPases Rac1 and Cdc42/c-Jun N-terminal kinase axis resulting in the activation of paxillin, NF-κB, and matrix metalloproteinase-2 (MMP-2).
|
25505176 |
2015 |
melanoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
RAC1 P29S regulates PD-L1 expression in melanoma.
|
26176707 |
2015 |
melanoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest RAC1 P29S status may offer a predictive biomarker for RAF inhibitor resistance in melanoma patients, where it should be evaluated clinically.
|
25056119 |
2014 |
melanoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The example of Sox10 and Rac1 genes provides detailed illustration of how interfering with these important genes for neural crest development can prevent melanoma formation.
|
24441506 |
2014 |
melanoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
RAC1 mutations are infrequent in primary melanomas but may accelerate disease progression.
|
25043693 |
2014 |
melanoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The melanoma RAC1(P29S) gain-of-function point mutation therefore represents a previously undescribed class of cancer-related GTPase activity.
|
23284172 |
2013 |
melanoma
|
0.600 |
Biomarker
|
disease |
CTD_human |
Notably, we identified a recurrent UV-signature, an activating mutation in RAC1 in 9.2% of sun-exposed melanomas.
|
22842228 |
2012 |
melanoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Notably, we identified a recurrent UV-signature, an activating mutation in RAC1 in 9.2% of sun-exposed melanomas.
|
22842228 |
2012 |
melanoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In contrast to the proliferation-related activity, CYLD knockdown significantly decreased the cell migration of all the melanoma cell lines (n=7, p<0.05), and we demonstrated that the mechanism regulating melanoma cell migration was activation of RAC1 through the action of CYLD.
|
22469839 |
2012 |
melanoma
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
These data indicate that Rac1 activity in FEMX cells regulates cell proliferation and invasion, in part via its effect on NFkappaB, signifying Rac1 as a key molecule in melanoma progression and metastasis.
|
17904119 |
2007 |
melanoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
In the present study, we investigated the molecular mechanisms underlying apoptosis regulation by Rac1 through functional proteomic analysis of three human melanoma M14 cell lines stably transfected with constitutively active Rac1V12, dominant negative Rac1N17, and empty vector (pIRES), respectively.
|
17952876 |
2007 |
melanoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The identification of SDF-1alpha as a potential stimulatory molecule for MT1-MMP as well as for RhoA and Rac1 activities during melanoma cell invasion, associated with an up-regulation in CXCR4 expression by interaction with basement membrane factors, could contribute to better knowledge of mechanisms stimulating melanoma cell dissemination.
|
15059909 |
2004 |
melanoma
|
0.600 |
CausalMutation
|
disease |
CGI |
|
|
|
MENTAL RETARDATION, AUTOSOMAL DOMINANT 48
|
0.600 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Heart failure
|
0.500 |
Biomarker
|
disease |
CTD_human |
The majority of these mice displayed severe hypertrophy (heart-to-body weight ratios >2-fold greater in the Rac1 mice) and died from overt heart failure between days 14 and 17.
|
16155095 |
2005 |