RAD51, RAD51 recombinase, 5888

N. diseases: 363; N. variants: 16
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4551570
Disease: 2-3 toe syndactyly
2-3 toe syndactyly 		0.100 GeneticVariation disease CLINVAR
CUI: C4025756
Disease: Abnormal aortic morphology
Abnormal aortic morphology 		0.100 Biomarker disease HPO
CUI: C4025211
Disease: Abnormal carotid artery morphology
Abnormal carotid artery morphology 		0.100 Biomarker disease HPO
CUI: C4020968
Disease: Abnormal localization of kidney
Abnormal localization of kidney 		0.100 Biomarker disease HPO
CUI: C3164445
Disease: Abnormality of aortic valve
Abnormality of aortic valve 		0.100 Biomarker disease HPO
CUI: C4551705
Disease: Abnormality of chromosome stability
Abnormality of chromosome stability 		0.100 Biomarker phenotype HPO
CUI: C4021750
Disease: Abnormality of femur morphology
Abnormality of femur morphology 		0.100 Biomarker disease HPO
CUI: C4025704
Disease: Abnormality of the corticospinal tract
Abnormality of the corticospinal tract 		0.100 Biomarker phenotype HPO
CUI: C0281842
Disease: Abnormality of the fallopian tube
Abnormality of the fallopian tube 		0.100 Biomarker phenotype HPO
CUI: C4025819
Disease: Abnormality of the hypothalamus-pituitary axis
Abnormality of the hypothalamus-pituitary axis 		0.100 Biomarker disease HPO
CUI: C4021780
Disease: Abnormality of the liver
Abnormality of the liver 		0.100 Biomarker phenotype HPO
CUI: C1846460
Disease: Abnormality of the outer ear
Abnormality of the outer ear 		0.100 Biomarker disease HPO
CUI: C4022016
Disease: Abnormality of the preputium
Abnormality of the preputium 		0.100 Biomarker disease HPO
CUI: C0342526
Disease: Absent testes
Absent testes 		0.100 Biomarker phenotype HPO
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.010 PosttranslationalModification disease BEFREE RAD51 gene plays an important role in the pathogenesis of squamous cell carcinoma of the head and neck (SCCHN), colorectal cancer, ovarian cancer and acute leukaemia. 24457040 2014
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia 		0.300 Biomarker disease GENOMICS_ENGLAND Germline Genetic Predisposition to Hematologic Malignancy. 28297620 2017
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.030 AlteredExpression group BEFREE Rad51 expression in adenocarcinoma was significantly higher than normal colonic tissue (p < 0.05). 28099437 2017
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.030 Biomarker group BEFREE The positive rates of RAD51 were 70.2% and 65.4% in high- and low-grade serous adenocarcinomas, respectively (P < 0.05 vs. the control specimens; low- vs. high-grade: P > 0.05). 28139510 2017
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.030 Biomarker group LHGDN Autoantibodies in sera of pancreatic cancer patients identify recombination factor Rad51 as a tumour-associated antigen. 11935313 2002
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.010 GeneticVariation disease BEFREE EGFR-RAD51 fusion variant in lung adenocarcinoma and response to erlotinib: A case report. 29290255 2018
CUI: C0281361
Disease: Adenocarcinoma of pancreas
Adenocarcinoma of pancreas 		0.020 AlteredExpression disease BEFREE Strikingly, over-expression of wild-type Rad51 was also found in 66% of human pancreatic adenocarcinoma tissue specimens. 10851081 2000
CUI: C0281361
Disease: Adenocarcinoma of pancreas
Adenocarcinoma of pancreas 		0.020 Biomarker disease BEFREE This observation identifies Rad51 as a tumour-associated antigen in pancreatic adenocarcinoma. 11935313 2002
CUI: C0001430
Disease: Adenoma
Adenoma 		0.010 AlteredExpression group BEFREE RAD51 mRNA expression was investigated by reverse transcription-polymerase chain reaction (RT-PCR), and sequence analysis of the entire coding region of the RAD51 cDNA was performed in all nine adenomas. 10583305 1999
CUI: C0278595
Disease: Adult Fibrosarcoma
Adult Fibrosarcoma 		0.010 Biomarker disease BEFREE In order to study the effects of acute HsRad51 ectopic overexpression on cell proliferation, cell cycle progression, and apoptosis, we generated clones of the human fibrosarcoma cell line HT1080 carrying a HsRad51 transgene under a repressible promoter. 11461118 2001
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.060 GeneticVariation disease BEFREE Rad51 Degradation: Role in Oncolytic Virus-Poly(ADP-Ribose) Polymerase Inhibitor Combination Therapy in Glioblastoma. 28376211 2017