|
Ataxia Telangiectasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
These have resulted in higher resolution structural models of the signalling proteins ATM (ataxia telangiectasia mutated), and ATR (ataxia telangiectasia and Rad3-related protein), along with various structures of Rad51.
|
31748913 |
2020 |
|
Diffuse Large B-Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The differential gene expression signature revealed enrichment of inflammatory markers, as previously observed in MZL, while tMZL and de novo DLBCL were enriched for extracellular matrix proteins such as collagen and fibronectin, vascular development protein PDGFRβ, DNA repair protein RAD51, and oncogenic secrete protein Wnt11.
|
31804739 |
2020 |
|
Tooth Attrition
|
0.010 |
Biomarker
|
disease |
BEFREE |
The BRCA-encoded products form complexes with other tumor suppressor proteins and with the recombinase enzyme RAD51 to mediate chromosome damage repair by homologous recombination and also to protect stressed DNA replication forks against spurious nucleolytic attrition.
|
30917004 |
2019 |
|
Rectal Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To the best of our knowledge, this is the first study to provide evidence for the positive effect of CC genotype of RAD51 or low Ku70 expression on OS in females with rectal cancer after SCRT.
|
30289394 |
2019 |
|
Squamous cell carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Combined effects of RAD51 (rs1801320 and rs1801321) and XRCC3 (rs861539) SNPs with environmental carcinogens (tobacco and alcohol) are associated with oral and oropharyngeal SCC development.
|
30033552 |
2019 |
|
Leukemia, T-Cell
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results demonstrated that RAD51 may be of great value to as a novel target for the clinical treatment of adult T‑cell leukemia‑lymphoma (ATL), and it may improve the survival of leukemia patients.
|
31638261 |
2019 |
|
Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of Rad51 predicts poor prognosis and silencing of Rad51 increases chemo-sensitivity to doxorubicin in neuroblastoma.
|
31632548 |
2019 |
|
Papilloma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In agreement with reported findings, RAS- and human papilloma virus type 16 E7-mediated transformation of human fibroblasts increased replication stress, as indicated by induction of multiple DNA damage responses (including formation of Rad51 foci).
|
30648820 |
2019 |
|
Uterine Fibroids
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The RNA and protein levels of key DNA repair members belonging to DNA DSB sensors (MRE11, NBS1, RAD50), mediators and effectors (CHECK2, BRCA1, RAD51) were downregulated in UFs compared with myometrial cells.
|
30478352 |
2019 |
|
Oropharyngeal disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
This study investigated the influence of single nucleotide polymorphisms (SNP) in RAD51 and XRCC3 on susceptibility to oral and oropharyngeal squamous cell carcinomas (SCC) and determined their clinicopathological significance.
|
30033552 |
2019 |
|
Central neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of Rad51 predicts poor prognosis and silencing of Rad51 increases chemo-sensitivity to doxorubicin in neuroblastoma.
|
31632548 |
2019 |
|
Therapy-related myelodysplastic syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Therapy-related MDS (t-MDS) demonstrated a significant downregulation of axis BRCA1-BRCA2-RAD51 comparing to normal controls (p = 0.048, p = 0.001, p = 0.001).
|
31667665 |
2019 |
|
Hereditary Malignant Neoplasm
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Numerous epidemiological studies have linked RAD51 paralog mutations with hereditary cancer predisposition.
|
30836272 |
2019 |
|
Desmoplastic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A significant association between the RAD51 172G>T polymoprhism and desmoplastic reaction of colorectal cancer was demonstrated.
|
30358196 |
2019 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Mechanistically, ChIP assays demonstrated that JQ1 decreased the association of BRD4 and BRD2 with promoter loci of Ku80 and RAD51, and shRNA data showed that expression of Ku80 and RAD51 was BRD4- and BRD2-dependent in PDAC cell lines.
|
31126889 |
2019 |
|
Oestrogen receptor positive breast cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results indicated that methylation of BRCA2 led to incomplete suppression on RAD51, which caused an increased expression of RAD51, subsequently AI-resistance and poor prognosis in ER-positive breast cancer.
|
31506496 |
2019 |
|
Childhood Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of Rad51 predicts poor prognosis and silencing of Rad51 increases chemo-sensitivity to doxorubicin in neuroblastoma.
|
31632548 |
2019 |
|
High-Risk Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings demonstrated for the first time that Rad51 is a prognostic marker in NB and down-regulation of Rad51 can lead to chemo-sensitizing effect in human NB cells.
|
31632548 |
2019 |
|
Cockayne Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the localization of RAD51 to damage sites during TC-HR does not require BRCA1 and BRCA2, but relies on RAD52 and Cockayne Syndrome Protein B (CSB).
|
30297739 |
2018 |
|
Ependymoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We also found RAD51, another DNA repair gene, was up-regulated in supratentorial and infratentorial ependymomas.
|
29416789 |
2018 |
|
Liver diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Together, the data suggest that the RAD51-mediated effects of HGF prevent hMSC senescence by promoting telomere lengthening and inducing mtDNA replication and function, which opens the prospect of developing novel therapies for liver disease.
|
29398486 |
2018 |
|
Chagas Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
In Trypanosoma cruzi, the etiologic agent of Chagas disease, Rad51 (TcRad51) is a central enzyme for homologous recombination.
|
30422982 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
EGFR-RAD51 fusion variant in lung adenocarcinoma and response to erlotinib: A case report.
|
29290255 |
2018 |
|
Malignant neoplasm of nasopharynx
|
0.010 |
Biomarker
|
disease |
BEFREE |
RPA1 downregulation enhances nasopharyngeal cancer radiosensitivity via blocking RAD51 to the DNA damage site.
|
30144445 |
2018 |
|
Cancer of Nasopharynx
|
0.010 |
Biomarker
|
disease |
BEFREE |
RPA1 downregulation enhances nasopharyngeal cancer radiosensitivity via blocking RAD51 to the DNA damage site.
|
30144445 |
2018 |