|
ovarian neoplasm
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study is to determine whether the location of mutations in the RAD51-binding domain (RAD51-BD; exon 11) of <i>BRCA2</i> gene affects the clinical outcome of ovarian cancer patients.<b>Experimental Design:</b> A study cohort of 353 women with ovarian cancer who underwent genetic germline testing for <i>BRCA1</i> and <i>BRCA2</i> genes was identified.
|
29084914 |
2018 |
|
ovarian neoplasm
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study is the first evaluation of the five RAD51 paralogs in breast and ovarian cancer predisposition and it demonstrates that deleterious variants can be present in breast cancer only cases.
|
29255180 |
2017 |
|
ovarian neoplasm
|
0.200 |
Biomarker
|
disease |
BEFREE |
RAD51 and BRCA2 Enhance Oncolytic Adenovirus Type 5 Activity in Ovarian Cancer.
|
26452665 |
2016 |
|
ovarian neoplasm
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The RAD51 paralog RAD51C has been identified as a breast and ovarian cancer susceptibility gene.
|
25292178 |
2015 |
|
ovarian neoplasm
|
0.200 |
Biomarker
|
disease |
BEFREE |
RAD51 gene plays an important role in the pathogenesis of squamous cell carcinoma of the head and neck (SCCHN), colorectal cancer, ovarian cancer and acute leukaemia.
|
24457040 |
2014 |
|
ovarian neoplasm
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis indicates that the BRCC5 polymorphism may be a candidate modifier of ovarian cancer risk in Caucasians.
|
24927671 |
2014 |
|
ovarian neoplasm
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
There was no significant association between RAD51 135 G>C polymorphism and risk of ovarian cancer.
|
24599673 |
2014 |
|
ovarian neoplasm
|
0.200 |
Biomarker
|
disease |
BEFREE |
RAD51 is an essential protein for catalyzing homologous recombination and its recruitment to DSBs is mediated by many factors including RAD51, its paralogs, and breast/ovarian cancer susceptibility gene products BRCA1/2.
|
24088786 |
2013 |
|
ovarian neoplasm
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
It confirms that RAD51 paralog mutations confer breast and ovarian cancer predisposition and are rare events.
|
24139550 |
2013 |
|
ovarian neoplasm
|
0.200 |
Biomarker
|
disease |
BEFREE |
Further, the association with RAD51 paralogs suggests HELQ as a candidate ovarian cancer gene.
|
24005565 |
2013 |
|
ovarian neoplasm
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the RAD51 C allele seems to protect against both breast and ovarian cancer in women harboring BRCA1 mutations.
|
17301259 |
2007 |
|
ovarian neoplasm
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Jewish non-Ashkenazi women at high-risk for breast/ovarian cancer and ethnically matched controls were genotyped using four single nucleotide polymorphisms spanning the RAD51 genomic region, and the resulting haplotypes were constructed using the GERBIL algorithm.
|
16624550 |
2006 |
|
ovarian neoplasm
|
0.200 |
Biomarker
|
disease |
BEFREE |
BRCA2 keeps Rad51 in line. High-fidelity homologous recombination prevents breast and ovarian cancer?
|
12504001 |
2002 |
|
ovarian neoplasm
|
0.200 |
Biomarker
|
disease |
BEFREE |
RAD51 status did not affect ovarian cancer risk.
|
11248061 |
2001 |
|
ovarian neoplasm
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We have identified a RAD51 5' untranslated region SNP that may be associated with an increased risk of breast cancer and a lower risk of ovarian cancer among BRCA2 mutation carriers.
|
11535547 |
2001 |
|
ovarian neoplasm
|
0.200 |
Biomarker
|
disease |
BEFREE |
BRCA1 and BRCA2 account for most cases of familial, early onset breast and/or ovarian cancer and encode products that each interact with hRAD51.
|
9774970 |
1998 |
|
ovarian neoplasm
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|