|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Neutrophil Cathepsin G and Tumor Cell RAGE Facilitate Neutrophil Anti-Tumor Cytotoxicity.
|
31428521 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The chronic inflammatory, hyperglycemic milieu accompanied by glycoxidative stress as in diabetes and obesity, concomitant with the formation of RAGE ligands, instigates RAGE and cancer stem cells, leading to the oncogenic transformation of normal and pre-malignant tissues towards development of neoplasms.
|
29987748 |
2018 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These findings provide evidence that the variant A allele of rs2070600 may decrease the expression of the tumour suppressor gene RAGE, thereby increasing lung cancer risk.
|
29421442 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
High glucose promotes tumor cell proliferation and migration in lung adenocarcinoma via the RAGE‑NOXs pathway.
|
29693146 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
RAGE-knockout mice displayed striking impairment of tumor cell growth compared with wild-type mice, along with decreased mitogen-activated protein kinase signaling, tumor angiogenesis and inflammatory cell recruitment.
|
27669433 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this study we suggest that extracellular HMGB1 interaction with RAGE enhances expression of oncogenic cluster miR221/222 that in turn inhibits tumor suppressor gene PTEN in two cell lines derived from human thyroid anaplastic and papillary cancers.
|
26106610 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
RAGE is a central driver of tumorigenesis by sustaining an inflammatory tumor microenvironment.
|
26018980 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interestingly, hypoxia and inflammation have been sequentially bridged in tumors by the discovery that alarmin receptors genes such as RAGE, P2X7 and some TLRs are activated by HIF-1α; and that, in turn, alarmin receptors strongly activate NF-κB and proinflammatory gene expression, evidencing all the hallmarks of the malignant phenotype.
|
24286852 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In the EL-4 lymphoma model tumor growth inhibition was observed in S100A9(-/-) and TLR4(-/-), but not in RAGE(-/-) animals lacking an alternative S100A9 receptor.
|
22470535 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Overexpression of RAGE was significantly correlated with the presence of multiple tumors (P = 0.021), high alfa-fetoprotein level (P = 0.042), and advanced tumor stage (P = 0.016).
|
21717246 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
RAGE-knockout animals are less susceptible to acute inflammation and carcinogen-induced tumor development.
|
19834494 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Fueling inflammation at tumor microenvironment: the role of multiligand/RAGE axis.
|
20028726 |
2010 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Pharmacological blockade of RAGE or genetic deletion of RAGE imparts significant protection in murine models of diabetes, inflammatory conditions, Alzheimer's disease, and tumors.
|
19477910 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
RAGE expression in rhabdomyosarcoma cells results in myogenic differentiation and reduced proliferation, migration, invasiveness, and tumor growth.
|
17640970 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
RAGE ligands derived from cancer cells can also influence a variety of important cell types within the tumor microenvironment, including fibroblasts, leukocytes, and vascular cells, leading to increased fibrosis, inflammation, and angiogenesis.
|
18331236 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Expression analysis of S100 proteins and RAGE in human tumors using tissue microarrays.
|
12859967 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In order to define possible targets for immune therapy, we evaluated the frequency of two groups of tumor antigens-the RAGE and GAGE families-by means of reverse transcriptase polymerase chain reaction using primary HNSCCs (n = 28), mucosa specimens as normal controls (n = 10) and HNSCC cell lines (n = 6).
|
12206267 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study, we have investigated the mRNA expression of the cancer germ-line genes MAGE, BAGE, GAGE, RAGE and the tumor-overexpressed gene PRAME by human myeloma cell lines and malignant plasma cells from patients with multiple myeloma (MM).
|
10741395 |
2000 |