The present study assessed the importance of immunity in angiotensin (ANG) II (5 ng·kg<sup>-1</sup>·min<sup>-1</sup> iv)-mediated hypertension in Dahl salt-sensitive (SS) rats and SS rats deficient in T and B lymphocytes (SS<sup>Rag1-/-</sup>) fed a 0.4% NaCl diet.
Resistance to angiotensin II (Ang II)-induced hypertension in T-cell-deficient male mice with a targeted mutation in the recombination-activating gene-1 (<i>Rag1</i>) on the C57BL/6J background (B6.<i>Rag1<sup>-/-</sup></i> -M), which was reported by 5 independent laboratories including ours before 2015, has been lost.
We compared indices of pulmonary hypertension resulting from chronic hypoxia (3 wk) in wild-type mice and recombination-activating gene 1 knockout mice (RAG1<sup>-/-</sup>, lacking mature T and B cells).