|
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
However, in immunodeficient B6/ Rag1 <sup>-/-</sup> and NOG mice, the same treatment failed to control tumor growth, further proving that the attenuation of tumor growth by tumor acidity modulation was attributable to the activation of tumor-infiltrating immune cells.
|
30943039 |
2019 |
|
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
Generation of Immunodeficient Rats With Rag1 and Il2rg Gene Deletions and Human Tissue Grafting Models.
|
29688994 |
2018 |
|
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
Here, the long-term effects of a 23% Western high-fat diet (HFD) in two immunodeficient mouse strains (NOD/SCID and Rag1 <sup>-/-</sup>) suitable for engraftment with human-derived tissue xenografts, and the effect of diet-induced hyperinsulinaemia on human prostate cancer cell line xenograft growth, were investigated.
|
28352127 |
2017 |
|
Immunologic Deficiency Syndromes
|
0.200 |
GeneticVariation
|
group |
BEFREE |
We aimed to assess engraftment, vasculogenic and pro-angiogenic activities of ECFC in immunocompetent (C57BL/6: WT) or immunodeficient (rag1 <sup>-/-</sup> C57BL/6: Rag1) mice.
|
29051567 |
2017 |
|
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
To define the immunodeficient status of rag1 <sup>-/-</sup> zebrafish, we obtained further functional evidence on T- and B-cell deficiency in the fish at the protein, cellular, and organism levels.
|
28790360 |
2017 |
|
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
Data herein show that we generated an immunodeficient hyperinsulinemic mouse by crossing the Rag1(-/-) mice, which have no mature B or T lymphocytes, with the MKR mouse model of T2D to generate the Rag1(-/-) (Rag/WT) and Rag1(-/-)/MKR(+/+) (Rag/MKR) mice.
|
27435064 |
2016 |
|
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
In contrast, severely immunodeficient NOD-scid and NOD-Rag1 (null) strains carrying the IL2rg (null) mutation (NSG and NRG) support the growth of many types of human primary tumors.
|
24798995 |
2014 |
|
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
Recently, the development of several stocks of immunodeficient Prkdc ( scid ) (scid) and recombination activating 1 or 2 gene (Rag1 or Rag2) knockout mice bearing a targeted mutation in the gene encoding the IL2 receptor gamma chain (IL2rgamma) have been reported.
|
20012395 |
2010 |
|
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
VBNC L. monocytogenes were tested for virulence in a cell plaque assay and by intraperitoneally inoculation in immunodeficient RAG1(-/-) mice.
|
19796607 |
2010 |
|
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
Neurobehavioral responses and cytokine levels were assessed in a transgenic mouse model in which the vpr transgene was expressed in an immunodeficient background (vpr/RAG1(-/-)).
|
20628092 |
2010 |
|
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
T- and B-cell immunodeficient mice (RAG1-/-) received passively transferred anti-C3H antibody, raised in B6 mice.
|
19696629 |
2009 |
|
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
We further demonstrated that MPTP-induced dopaminergic cell death was markedly attenuated in the absence of mature T lymphocytes in 2 different immunodeficient mouse strains (Rag1-/- and Tcrb-/- mice).
|
19104149 |
2009 |
|
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
These data document that Rag1(null) and scid stocks of immunodeficient NOD mice harbouring the IL2rgamma(null) mutation support similar levels of human lymphohaematopoietic cell engraftment.
|
18785974 |
2008 |
|
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
By generating immunodeficient mice (in Rag-1-/- or nude background) deleted for PAI-1 gene (PAI-1-/-), we have evaluated the impact of host PAI-1 deficiency on the tumorigenicity of two malignant human skin keratinocyte cell lines HaCaT II-4 and HaCaT A5-RT3 forming low-grade and high-grade carcinomas, respectively.
|
15720817 |
2005 |
|
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
To assess the effect of the difference in cancer cell types on the recruitment of BMD-VE and BMD-MF, 10 kinds of human cancer cell line were implanted into the subcutaneous tissue of the immunodeficient mice transplanted with bone marrow of double-mutant mice (RAG-1-/- beta-gal Tg or RAG-1-/- GFP Tg).
|
15729726 |
2005 |
|
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
Finally, in an in vivo transfer model of asthma in immunodeficient Rag1 mice, CD4+CD25+ T cells isolated from anti-IL-6R antibody-treated mice exhibited marked immunosuppressive and antiinflammatory functions.
|
15668741 |
2005 |
|
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
We also show that degeneration of host muscles by the myotoxin barium chloride (BaCl(2)) resulted in the greatest amount of regenerating human muscle fibres in both the severe combined immunodeficient and RAG-1 mice.
|
15099593 |
2004 |
|
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice.
|
15308121 |
2004 |
|
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
Though an immune infiltrate was present occasionally in transgenic skin, the infiltrate was not the primary cause of the epithelial hyperproliferation, as the immune reaction was not observed in all affected transgenics, and the transgene induced identical skin and urinary tract abnormalities in immunodeficient Rag1-null mice.
|
10419685 |
1999 |
|
Immunologic Deficiency Syndromes
|
0.200 |
GeneticVariation
|
group |
CLINVAR |
|
|
|