Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
Immunodeficient RAG2 knock-out mice were unable to control infection with TDP1-overexpressing parasites, showing that the adaptive immune response is critical to reducing disease severity.
|
31554700 |
2019 |
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
We used RAG2-knockout immunodeficient swine.
|
31138877 |
2019 |
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
Comparison studies were carried out in 1-month-old (clinical onset of the disease) and 7-month-old control mice (C57Bl/6J, Rag2/γc-null) and immunocompetent and immunodeficient dystrophic mice (Sgcb-null and Sgcb/Rag2/γc-null, respectively).
|
29476695 |
2018 |
Immunologic Deficiency Syndromes
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Here, we created an immunodeficient rat with a functional deletion of the Recombination Activating Gene 2 (<i>Rag2</i>) gene, using genetically modified spermatogonial stem cells (SSC).
|
30206106 |
2018 |
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
Interestingly, elderly MABs displayed a dramatic impairment in the myogenic differentiation ability in vitro and when transplanted in dystrophic immunodeficient Sgcb-null Rag2-null γc-null mice.
|
29397577 |
2018 |
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
HFD-BALBc-Rag2/IL2-gc female mice (n = 24) were used as HFD-immunodeficient controls.
|
28193233 |
2017 |
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
In this study, we examined the influence of delivering adult-derived human liver stem/progenitor cells (ADHLSCs) at two different early time points in an immunodeficient mouse model (Rag2-/-IL2Rγ-/-) that had undergone a 70% hepatectomy procedure.
|
27657746 |
2017 |
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
When h-γδ T cells were injected into ZOL-treated immunodeficient (Rag2(-/-) ZOL) mice, the oral epithelial hyperplasia developed.
|
26013832 |
2015 |
Immunologic Deficiency Syndromes
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The RAG1-RAG2 structure rationalizes more than 60 mutations identified in immunodeficient patients, as well as a large body of genetic and biochemical data.
|
25707801 |
2015 |
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
Adoptive transfer of these T-cells suppressed tumor progression in Raji tumor-bearing Rag2(-/-)γc(-/-) immunodeficient mice compared with control mice.
|
25427612 |
2015 |
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
Here, hMSC were differentiated into hepatocyte-like cells in vitro (hMSC-HC) and transplanted into livers of immunodeficient Pfp/Rag2⁻/⁻ mice treated with a sublethal dose of acetaminophen (APAP) to induce acute liver injury.
|
24758938 |
2014 |
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
They contribute to extensive muscle regeneration and satellite cell formation following intramuscular transplantation into irradiated and cryodamaged tibialis anterior muscles of immunodeficient Rag2-/γ chain-/C5-mice.
|
24569833 |
2014 |
Immunologic Deficiency Syndromes
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Previously, we established that facial MN (FMN) survival levels in the SOD1(G93A) transgenic mouse model of ALS are reduced and nerve regeneration is delayed, similar to immunodeficient RAG2(-/-) mice, after facial nerve axotomy.
|
24911596 |
2014 |
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
Furthermore, these cells efficiently accumulated at Raji tumor lesions where they suppressed tumor progression and prolonged survival in tumor-bearing Rag2(-/-)γc(-/-) immunodeficient mice compared to control cohorts.
|
23872144 |
2013 |
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
The Rag2⁻Il2rb⁻Dmd⁻ mouse: a novel dystrophic and immunodeficient model to assess innovating therapeutic strategies for muscular dystrophies.
|
23975040 |
2013 |
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
We engrafted human pancreatic islets of Langerhans into the renal subcapsular space of immunodeficient BALB/c.rag2(-/-).cγ(-/-) mice, previously rendered diabetic via injection of the β-cell toxin streptozocin.
|
23917725 |
2013 |
Immunologic Deficiency Syndromes
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The human ovarian carcinoma SK-OV-3 cells implanted intraperitoneally (i.p.) in immunodeficient Rag2⁻/⁻;Il2rg⁻/⁻ mice gave rise to a progressive peritoneal carcinomatosis which mimics the fatal condition in advanced human patients.I.p. administration of R-LM249 strongly inhibited carcinomatosis, resulting in 60% of mice free from peritoneal diffusion, and 95% reduction in the total weight of neoplastic nodules.
|
23382683 |
2013 |
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
To address this hypothesis, we used three mouse strains (non-obese diabetic (NOD)/severe-combined immunodeficient (SCID) (N/S); NOD/SCID γ-chain(-/-) (NSG); and Rag2(-/-) γ-chain(-/-) (DKO)) and two humanization techniques (bone marrow liver thymus (BLT) and human CD34(+) cell bone marrow transplant of newborn mice (hu)) to generate four common types of humanized mice: N/S-BLT, NSG-BLT, NSG-hu, and DKO-hu mice.
|
22569301 |
2012 |
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
Since the early 2000s, a series of immunodeficient mice appropriate for generating humanized mice has been successively developed by introducing the IL-2Rγ(null) gene (e.g., NOD/SCID/γc(null) and Rag2(null)γc(null) mice).
|
22327211 |
2012 |
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
We therefore developed a mouse model for SS using intrahepatic injection of SS cells in newborn immunodeficient RAG2(-/-) γc(-/-) mice that are completely devoid of T-, B- and NK-cell activity.
|
22897578 |
2012 |
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
Here, we investigated whether human macrophages, either proinflammatory or anti-inflammatory, coinjected with human myoblasts into regenerating muscle of Rag2(-/-) γC(-/-) immunodeficient mice, could modify in vivo the kinetics of proliferation and differentiation of the transplanted human myogenic precursors.
|
23070116 |
2012 |
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
Biopsy specimens from patients with active GPA (n = 10) or sinusitis (controls, n = 6) were s.c. co-implanted with healthy allogeneic human nasal cartilage into immunodeficient pfp/rag2(-/-) mice.
|
22449947 |
2012 |
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
MTDIA treatment inhibited A549 (human non-small cell lung carcinoma) and H358 (human bronchioloalveolar non-small cell lung carcinoma cells) xenograft tumor growth in immunodeficient Rag2(-/-)γC(-/-) and NCr-nu mice.
|
21135097 |
2011 |
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
Experimental intranasal infection of Rag2-immunodeficient mice with these isolates led to severe brain pathologies, and viable trophozoites were isolated from the nasal mucosa, brain tissue, and lungs post mortem.
|
20036656 |
2010 |
Immunologic Deficiency Syndromes
|
0.200 |
Biomarker
|
group |
BEFREE |
Recently, the development of several stocks of immunodeficient Prkdc ( scid ) (scid) and recombination activating 1 or 2 gene (Rag1 or Rag2) knockout mice bearing a targeted mutation in the gene encoding the IL2 receptor gamma chain (IL2rgamma) have been reported.
|
20012395 |
2010 |