RAG2, recombination activating 2, 5897

N. diseases: 207; N. variants: 44
Disease: Lymphoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.140 Biomarker group BEFREE CLT chimeric mice generated by this RAG2-deficient blastocyst complementation ("RDBC") approach die rapidly in association with B-cell lymphoproliferation and lymphoma. 25934172 2015
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.140 Biomarker group BEFREE Accordingly, by combining in vitro and in vivo studies of human BL-xenografts grown in immunodeficient RAG2(-/-)γc(-/-) mice and of murine B220(+)IgM(+) B-cell lymphomas generated in Eμ-MYC and Eμ-MYC-BIM(+/-) transgenes, we demonstrate that lymphoma chemoresistance is dictated by BIM gene dosage and is reversible on BIM reactivation by genetic manipulation or after treatment with histone-deacetylase inhibitors. 20570860 2010
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.140 Biomarker group BEFREE RAG2/TYK2 double-knockout mice succumbed to A-MuLV-induced leukemia/lymphoma faster than RAG2(-/-)TYK2(+/-) mice. 15578097 2004
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.140 Biomarker group BEFREE Expression of the recombination activating genes (RAG1 and RAG2) is not detectable in Epstein-Barr virus-associated human lymphomas. 11279609 2001
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.140 Biomarker group HPO