|
Obesity
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
This study investigated the association of three single nucleotide polymorphisms (SNPs) in the BCHE gene: -116G > A (rs1126680), 1615GA (rs1803274), 1914A < G (rs3495), with obesity and lipid metabolism markers, body mass index (BMI), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglyceride (TG) levels, and BChE enzymatic activity in obese (BMI≥30/n = 226) and non-obese women (BMI < 25/n = 81).
|
28497838 |
2019 |
|
Obesity
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Effect of pomegranate extracts on brain antioxidant markers and cholinesterase activity in high fat-high fructose diet induced obesity in rat model.
|
28655305 |
2017 |
|
Obesity
|
0.390 |
Biomarker
|
disease |
BEFREE |
Butyrylcholinesterase gene transfer in obese mice prevents postdieting body weight rebound by suppressing ghrelin signaling.
|
28973869 |
2017 |
|
Obesity
|
0.390 |
Biomarker
|
disease |
BEFREE |
Our results indicate that BChE strongly affects fat metabolism, has an important impact on fat accumulation, and may be a promising tool for combating obesity.
|
27300766 |
2016 |
|
Obesity
|
0.390 |
Biomarker
|
disease |
CTD_human |
Potential anti-obesity effects of a long-acting cocaine hydrolase.
|
27163854 |
2016 |
|
Obesity
|
0.390 |
Therapeutic
|
disease |
CTD_human |
Potential anti-obesity effects of a long-acting cocaine hydrolase.
|
27163854 |
2016 |
|
Obesity
|
0.390 |
Therapeutic
|
disease |
CTD_human |
Effects of conjugated linoleic acid supplementation and exercise on post-heparin lipoprotein lipase, butyrylcholinesterase, blood lipid profile and glucose metabolism in young men.
|
23073171 |
2013 |
|
Obesity
|
0.390 |
Biomarker
|
disease |
CTD_human |
Effects of conjugated linoleic acid supplementation and exercise on post-heparin lipoprotein lipase, butyrylcholinesterase, blood lipid profile and glucose metabolism in young men.
|
23073171 |
2013 |
|
Obesity
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
These results show: (1) a protective effect of -116A and K variants on juvenile obesity risk, suggesting a role for the BCHE gene on juvenile onset obesity different from that observed on adult onset obesity and (2) an association of the -116A variant with hypertriglyceridemia in obese adolescents probably because of its effect on lowering BChE activity and consequently diminishing the enzyme capability of maintaining homeostasis on lipid metabolism during the metabolic stress caused by obesity.
|
23000450 |
2013 |
|
Obesity
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
The 1914G allele showed significantly higher frequency in the obese group, and carriers of 1914G allele showed lower mean BChE activity when compared to 1914A carriers (p=0.006).
|
24001779 |
2013 |
|
Obesity
|
0.390 |
Biomarker
|
disease |
CTD_human |
These results show: (1) a protective effect of -116A and K variants on juvenile obesity risk, suggesting a role for the BCHE gene on juvenile onset obesity different from that observed on adult onset obesity and (2) an association of the -116A variant with hypertriglyceridemia in obese adolescents probably because of its effect on lowering BChE activity and consequently diminishing the enzyme capability of maintaining homeostasis on lipid metabolism during the metabolic stress caused by obesity.
|
23000450 |
2013 |
|
Obesity
|
0.390 |
Therapeutic
|
disease |
CTD_human |
These results show: (1) a protective effect of -116A and K variants on juvenile obesity risk, suggesting a role for the BCHE gene on juvenile onset obesity different from that observed on adult onset obesity and (2) an association of the -116A variant with hypertriglyceridemia in obese adolescents probably because of its effect on lowering BChE activity and consequently diminishing the enzyme capability of maintaining homeostasis on lipid metabolism during the metabolic stress caused by obesity.
|
23000450 |
2013 |
|
Obesity
|
0.390 |
Biomarker
|
disease |
BEFREE |
Serum butyrylcholinesterase (BCHE) activity is associated with obesity, blood pressure and biomarkers of cardiovascular and diabetes risk.
|
21862451 |
2011 |
|
Obesity
|
0.390 |
Biomarker
|
disease |
BEFREE |
The BChE KO mouse becomes obese on a high-fat diet, suggesting a role for BChE in fat metabolism.
|
19416087 |
2009 |
|
Obesity
|
0.390 |
Biomarker
|
disease |
BEFREE |
However, BChE-/- mice fed a diet containing 11% fat became obese.
|
18452903 |
2008 |
|
Obesity
|
0.390 |
Therapeutic
|
disease |
CTD_human |
The butyrylcholinesterase knockout mouse is obese on a high-fat diet.
|
18452903 |
2008 |
|
Obesity
|
0.390 |
Biomarker
|
disease |
CTD_human |
The butyrylcholinesterase knockout mouse is obese on a high-fat diet.
|
18452903 |
2008 |