RAP1GAP, RAP1 GTPase activating protein, 5909

N. diseases: 63; N. variants: 4
Disease: Thyroid carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.340 Biomarker disease CTD_human Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma. 22614916 2012
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.340 Biomarker disease BEFREE Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma. 22614916 2012
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.340 Biomarker disease BEFREE RAP1GAP inhibits cytoskeletal remodeling and motility in thyroid cancer cells. 22696507 2012
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.340 AlteredExpression disease BEFREE Although activating mutations in Rap have not been described, downregulation of Rap1GAP is frequent in human tumors including thyroid carcinomas. 21367844 2011
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.340 AlteredExpression disease BEFREE In this study, we analyzed 197 thyroid tumor samples and showed that Rap1GAP was frequently lost or downregulated in various types of tumors, particularly in the most invasive and aggressive forms of thyroid cancer. 20124489 2010