|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
This is the first report of an NUP98 translocation in lymphocytic leukemia and the first time that RAP1GDS1 has been implicated in any human malignancy.
|
10477737 |
1999 |
|
Primary malignant neoplasm
|
0.070 |
Biomarker
|
group |
BEFREE |
This is the first report of an NUP98 translocation in lymphocytic leukemia and the first time that RAP1GDS1 has been implicated in any human malignancy.
|
10477737 |
1999 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
The (4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T-cell acute lymphocytic leukemia.
|
10477737 |
1999 |
|
Lymphoid leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
This is the first report of an NUP98 translocation in lymphocytic leukemia and the first time that RAP1GDS1 has been implicated in any human malignancy.
|
10477737 |
1999 |
|
Acute lymphocytic leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
t(4;11)(q21;p15) translocation involving NUP98 and RAP1GDS1 genes: characterization of a new subset of T acute lymphoblastic leukaemia.
|
10929031 |
2000 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Molecular evaluation of the NUP98/RAP1GDS1 gene frequency in adults with T-acute lymphoblastic leukemia.
|
11325654 |
2001 |
|
Childhood T Acute Lymphoblastic Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Molecular evaluation of the NUP98/RAP1GDS1 gene frequency in adults with T-acute lymphoblastic leukemia.
|
11325654 |
2001 |
|
Adult T Acute Lymphoblastic Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Molecular evaluation of the NUP98/RAP1GDS1 gene frequency in adults with T-acute lymphoblastic leukemia.
|
11325654 |
2001 |
|
Infant T Acute Lymphoblastic Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Molecular evaluation of the NUP98/RAP1GDS1 gene frequency in adults with T-acute lymphoblastic leukemia.
|
11325654 |
2001 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Twelve of them have been identified in patients with myeloid neoplasias and only 1, RAP1GDS1 (4q21), is fused with NUP98 in five patients with T-cell acute lymphoblastic leukemia (T-ALL).
|
12810632 |
2003 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Involvement of ADD3 and C6ORF80 genes were detected, respectively, in myeloid disorders and in T-cell acute lymphoblastic leukemia (T-ALL), whereas the RAP1GDS1 gene was fused to NUP98 in T-ALL.
|
16467868 |
2006 |
|
Leukemia, Myelocytic, Acute
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Rearrangements of NUP98 were identified in two patients, both showing 11p abnormalities in the diagnostic karyotype: a t(4;11)(q1?3;p15) with expression of the NUP98-RAP1GDS1 fusion product detected in a 60-year-old woman with AML-M0, and an add(11)(p15) with a der(21)t(11;21)(p15;p13) observed cytogenetically in a 1-year-old boy with AML-M7.
|
16419055 |
2006 |
|
Malignant Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
We report here that SmgGDS protein levels are elevated in NSCLC tumors, compared with normal lung tissue from the same patients or from individuals without cancer.
|
17951244 |
2008 |
|
Primary malignant neoplasm
|
0.070 |
AlteredExpression
|
group |
BEFREE |
We report here that SmgGDS protein levels are elevated in NSCLC tumors, compared with normal lung tissue from the same patients or from individuals without cancer.
|
17951244 |
2008 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
We report here that SmgGDS protein levels are elevated in NSCLC tumors, compared with normal lung tissue from the same patients or from individuals without cancer.
|
17951244 |
2008 |
|
Non-Small Cell Lung Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our finding that the aggressive NSCLC phenotype is more effectively suppressed by silencing SmgGDS than by silencing RhoA is consistent with the ability of SmgGDS to regulate multiple small GTPases in addition to RhoA.
|
17951244 |
2008 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
SmgGDS is a guanine nucleotide exchange factor with the unique ability to activate multiple small GTPases, implicating it in cancer development and progression.
|
18973191 |
2009 |
|
Primary malignant neoplasm
|
0.070 |
Biomarker
|
group |
BEFREE |
SmgGDS is a guanine nucleotide exchange factor with the unique ability to activate multiple small GTPases, implicating it in cancer development and progression.
|
18973191 |
2009 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
SmgGDS is up-regulated in prostate carcinoma and promotes tumour phenotypes in prostate cancer cells.
|
18973191 |
2009 |
|
Prostatic Intraepithelial Neoplasias
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical analysis revealed that SmgGDS levels were elevated in prostatic intraepithelial neoplasia (PIN), prostate carcinoma, and metastatic prostate carcinoma.
|
18973191 |
2009 |
|
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we investigated the role of SmgGDS in prostate cancer by studying the expression of SmgGDS in benign and malignant prostatic tissues.
|
18973191 |
2009 |
|
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Reduction of SmgGDS expression in prostate carcinoma cells inhibited proliferation and migration, irrespective of androgen receptor status.
|
18973191 |
2009 |
|
Metastatic Prostate Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical analysis revealed that SmgGDS levels were elevated in prostatic intraepithelial neoplasia (PIN), prostate carcinoma, and metastatic prostate carcinoma.
|
18973191 |
2009 |
|
Progression of prostate cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings suggest that SmgGDS promotes the development and progression of prostate cancer, possibly associated with NF-kappaB-dependent up-regulation of COX-2.
|
18973191 |
2009 |
|
Malignant Neoplasms
|
0.070 |
GeneticVariation
|
group |
BEFREE |
Our results indicate that the entrance and passage of these small GTPases through the prenylation pathway is regulated by two splice variants of SmgGDS, a protein that has been reported to promote GDP/GTP exchange by PBR-possessing GTPases and to be up-regulated in several forms of cancer.
|
20709748 |
2010 |