|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
SmgGDS undergoes nucleocytoplasmic shuttling, suggesting that it has both cytoplasmic and nuclear functions that promote cancer.
|
28806394 |
2017 |
|
Primary malignant neoplasm
|
0.070 |
Biomarker
|
group |
BEFREE |
SmgGDS undergoes nucleocytoplasmic shuttling, suggesting that it has both cytoplasmic and nuclear functions that promote cancer.
|
28806394 |
2017 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
This study demonstrates that elevated SmgGDS expression in breast tumors correlates with poor survival, and that SmgGDS-558 plays a functional role in breast cancer malignancy.
|
24197117 |
2014 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
These findings indicate that SmgGDS promotes cell cycle progression in multiple types of cancer, making SmgGDS a valuable target for cancer therapeutics.
|
24552806 |
2014 |
|
Primary malignant neoplasm
|
0.070 |
Biomarker
|
group |
BEFREE |
This study demonstrates that elevated SmgGDS expression in breast tumors correlates with poor survival, and that SmgGDS-558 plays a functional role in breast cancer malignancy.
|
24197117 |
2014 |
|
Primary malignant neoplasm
|
0.070 |
Biomarker
|
group |
BEFREE |
These findings indicate that SmgGDS promotes cell cycle progression in multiple types of cancer, making SmgGDS a valuable target for cancer therapeutics.
|
24552806 |
2014 |
|
Malignant Neoplasms
|
0.070 |
GeneticVariation
|
group |
BEFREE |
Our results indicate that the entrance and passage of these small GTPases through the prenylation pathway is regulated by two splice variants of SmgGDS, a protein that has been reported to promote GDP/GTP exchange by PBR-possessing GTPases and to be up-regulated in several forms of cancer.
|
20709748 |
2010 |
|
Primary malignant neoplasm
|
0.070 |
GeneticVariation
|
group |
BEFREE |
Our results indicate that the entrance and passage of these small GTPases through the prenylation pathway is regulated by two splice variants of SmgGDS, a protein that has been reported to promote GDP/GTP exchange by PBR-possessing GTPases and to be up-regulated in several forms of cancer.
|
20709748 |
2010 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
SmgGDS is a guanine nucleotide exchange factor with the unique ability to activate multiple small GTPases, implicating it in cancer development and progression.
|
18973191 |
2009 |
|
Primary malignant neoplasm
|
0.070 |
Biomarker
|
group |
BEFREE |
SmgGDS is a guanine nucleotide exchange factor with the unique ability to activate multiple small GTPases, implicating it in cancer development and progression.
|
18973191 |
2009 |
|
Malignant Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
We report here that SmgGDS protein levels are elevated in NSCLC tumors, compared with normal lung tissue from the same patients or from individuals without cancer.
|
17951244 |
2008 |
|
Primary malignant neoplasm
|
0.070 |
AlteredExpression
|
group |
BEFREE |
We report here that SmgGDS protein levels are elevated in NSCLC tumors, compared with normal lung tissue from the same patients or from individuals without cancer.
|
17951244 |
2008 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
This is the first report of an NUP98 translocation in lymphocytic leukemia and the first time that RAP1GDS1 has been implicated in any human malignancy.
|
10477737 |
1999 |
|
Primary malignant neoplasm
|
0.070 |
Biomarker
|
group |
BEFREE |
This is the first report of an NUP98 translocation in lymphocytic leukemia and the first time that RAP1GDS1 has been implicated in any human malignancy.
|
10477737 |
1999 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
The NUP98-RAP1GDS1 affected different hematopoietic lineages in AML and T-ALL.
|
26004809 |
2015 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Involvement of ADD3 and C6ORF80 genes were detected, respectively, in myeloid disorders and in T-cell acute lymphoblastic leukemia (T-ALL), whereas the RAP1GDS1 gene was fused to NUP98 in T-ALL.
|
16467868 |
2006 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Twelve of them have been identified in patients with myeloid neoplasias and only 1, RAP1GDS1 (4q21), is fused with NUP98 in five patients with T-cell acute lymphoblastic leukemia (T-ALL).
|
12810632 |
2003 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Molecular evaluation of the NUP98/RAP1GDS1 gene frequency in adults with T-acute lymphoblastic leukemia.
|
11325654 |
2001 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
The (4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T-cell acute lymphocytic leukemia.
|
10477737 |
1999 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
In addition, Kaplan-Meier survival curves indicated that patients with high SmgGDS expression in their tumors had worse clinical outcomes.
|
24197117 |
2014 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
SmgGDS is up-regulated in prostate carcinoma and promotes tumour phenotypes in prostate cancer cells.
|
18973191 |
2009 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
We report here that SmgGDS protein levels are elevated in NSCLC tumors, compared with normal lung tissue from the same patients or from individuals without cancer.
|
17951244 |
2008 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Taken together, our results support a novel nuclear role for SmgGDS in protecting malignant cells from nucleolar stress, thus promoting cell cycle progression and tumorigenesis.
|
28806394 |
2017 |
|
Leukemia, Myelocytic, Acute
|
0.020 |
Biomarker
|
disease |
BEFREE |
The NUP98-RAP1GDS1 affected different hematopoietic lineages in AML and T-ALL.
|
26004809 |
2015 |
|
Malignant neoplasm of breast
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
To examine the roles of SmgGDS splice variants in the cell cycle, we compared the effects of the RNAi-mediated depletion of SmgGDS-558 vs. SmgGDS-607 on cell cycle progression and the expression of cyclin D1, p27, and p21 in pancreatic, lung, and breast cancer cell lines.
|
24552806 |
2014 |