|
Malignant Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
RAS is a small GTP binding protein mutated in approximately 30% human cancer.
|
15940260 |
2005 |
|
Primary malignant neoplasm
|
0.030 |
GeneticVariation
|
group |
BEFREE |
RAS is a small GTP binding protein mutated in approximately 30% human cancer.
|
15940260 |
2005 |
|
CAPILLARY MALFORMATION-ARTERIOVENOUS MALFORMATION (disorder)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Capillary malformation-arteriovenous malformation (CM-AVM) is a blood and lymphatic vessel (LV) disorder that is caused by inherited inactivating mutations of the RASA1 gene, which encodes p120 RasGAP (RASA1), a negative regulator of the Ras small GTP-binding protein.
|
28530642 |
2017 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Small GTP-binding protein Rho stimulates the actomyosin system, leading to invasion of tumor cells.
|
9478968 |
1998 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Knockdown of Rap2B inhibited the proliferation, migration, and invasion of cervical cancer cells.
|
28390112 |
2018 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
miR-342-3p targets RAP2B to suppress proliferation and invasion of non-small cell lung cancer cells.
|
25663460 |
2015 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We propose that XIST is responsible for OS cell proliferation and invasion and that XIST exerts its function through the miR-320b/RAP2B axis.
|
28409547 |
2018 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Mechanically, RAP2B was identified as a direct target gene of miR-147b and RAP2B rescued the suppression of proliferation and invasion reduced by miR-147b in CRC cells.
|
31121595 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In addition, we disclosed the effect of Rap2B knockdown on cell adhesion, proliferation, migration and invasion by using cell attachment assay, CCK-8 assay, cell migration assay and Wound Healing assay, cell invasion assay, respectively.
|
30997639 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our data indicated that Rap2B expression is significantly increased in human suprarenal epithelioma and Rap2B can promote the cell migration and invasion abilities, which may provide a new target for the treatment of suprarenal epithelioma.
|
24951956 |
2014 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, our data suggest that Rap2B silencing inhibits the proliferation and invasion in HCC cells.
|
28081729 |
2017 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
As a confirmed target gene of p53, we believe that further investigating potential functions of Rap2B in autophagy and tumorigenesis will provide a novel strategy for cancer therapy.
|
29029384 |
2017 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Rap2B gene may play an important role in the process of lung cancer and global DNA hypomethylation might be an early event in tumorigenesis.
|
26308105 |
2015 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Increasing focus on Ras signaling pathway reveals critical effects of Rap2B on tumorigenesis.
|
27012552 |
2016 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
In addition, our tumorigenesis assay showed that Rap2B knockdown suppressed cervical cancer cell growth and metastasis in vivo.
|
28390112 |
2018 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Rap2B, belonging to the Ras superfamily, has been implicated in cancer development and functions as a tumor promoter.
|
28390112 |
2018 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Rap2B silencing obviously inhibited the proliferation, migration, and invasion of HCC cells, as well as attenuated xenografted tumor growth in vivo.
|
28081729 |
2017 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
However, the function of Rap2B in tumor angiogenesis that is necessary for tumor growth and metastasis remains unknown.
|
28691643 |
2017 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
The small GTP-binding protein Rab25 is associated with tumor formation and progression.
|
29371698 |
2018 |
|
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
However, the function of Rap2B in tumor angiogenesis that is necessary for tumor growth and metastasis remains unknown.
|
28691643 |
2017 |
|
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
In addition, our tumorigenesis assay showed that Rap2B knockdown suppressed cervical cancer cell growth and metastasis in vivo.
|
28390112 |
2018 |
|
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
The small GTP-binding protein Arf6 is known to be an important regulator of the actin cytoskeleton and of cell motility associated with metastasis.
|
19948141 |
2009 |
|
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
This study shows that the small GTP-binding protein ADP-ribosylation factor 6 (ARF6) is an important regulator of tumor growth and metastasis.
|
19276388 |
2009 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
In this review, we present recent studies on the structure, regulation, and multiple biological functions of Rap2B, shedding light on its potential status in treatment of cancer as well as other diseases.
|
27012552 |
2016 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Rap2B, belonging to the Ras superfamily, has been implicated in cancer development and functions as a tumor promoter.
|
28390112 |
2018 |