|
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
RARA is involved in translocation with PML in acute promyelocytic leukaemia (APL).
|
30996344 |
2019 |
|
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Basic pathogenic differences between classical APL and PLZF-RARα-associated APL are further discussed.
|
31126665 |
2019 |
|
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Acute promyelocytic leukemia (APL) is a distinct type of acute myeloid leukemia that is defined by the presence of the translocations that mostly involve the RARA gene.
|
31125631 |
2019 |
|
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
With RT-PCR and karyotype, Case A is diagnosed with STAT5b-RARα-positive APL.Case B, C are diagnosed with PLZF-RARα-positive APL.
|
31083206 |
2019 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
A hallmark of acute promyelocytic leukemia (APL) is the expression of PML/RARα fusion protein.
|
31592194 |
2019 |
|
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
This is the first report of an APL case presenting with submicroscopic ins(15;17) and simultaneous novel breakpoints in both PML and RARA.
|
31085908 |
2019 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Acute promyelocytic leukemia (APL) is characterized by a reciprocal translocation between chromosomes 15 and 17, t(15;17), resulting in the expression of PML-RARα fusion protein, which disrupts the normal PML nuclear bodies (PML-NBs) to micro-speckled pattern, leading to loss of their original functions.
|
31669778 |
2019 |
|
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
<i>TBL1XR1-RARB</i> as an oncogenic protein exerts effects similar to those of <i>PML-RARA</i>, underpinning the importance of retinoic acid pathway alterations in the pathogenesis of APL.<b>Significance:</b> These findings report a novel and distinct genetic subtype of acute promyelocytic leukemia (APL) by illustrating that the majority of APL without RARA translocations harbor RARB translocations.<i></i>.
|
29921692 |
2018 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We hypothesized that PML/RARA-mediated downregulation of <i>Irf8</i> transcript levels contributes to the initiation of APL.
|
30266821 |
2018 |
|
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
BRD4 interacts with PML/RARα in acute promyelocytic leukemia.
|
30552662 |
2018 |
|
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Mutation analysis of PML-RARA was performed using samples from a chemotherapy- and ATRA-resistant APL patient, and the frequencies of mutated PML-RARA transcript were analyzed by targeted deep sequencing.
|
30289902 |
2018 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Of 84 cases (63%) that lacked monocytic differentiation ("myeloid AML"), 40 (48%) demonstrated an acute promyelocytic leukemia-like (APL-like) immunophenotype by flow cytometry, with absence of CD34 and HLA-DR and strong myeloperoxidase expression, in the absence of a PML-RARA translocation.
|
29274134 |
2018 |
|
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
PML-RARα interferes with erythropoiesis by repressing LMO2 in acute promyelocytic leukaemia.
|
30320491 |
2018 |
|
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Furthermore, crocetin suppressed the expression of clinical marker promyelocytic leukemia/retinoic acid receptor-α ( PML/RARα) in NB4 and primary APL cells, and reduced the expression of histone deacetylase 1 ( HDAC1) in all leukemic cells.
|
30203596 |
2018 |
|
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Human acute promyelocytic leukemia (APL) cells are characterized by the arrest of differentiation at the promyelocytic stage due to epigenetic perturbations induced by PML/RARα fusion protein (Promyelocytic Leukemia protein - PML/Retinoic Acid Receptor alpha - RARα).
|
29590658 |
2018 |
|
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
All-trans retinoic acid and arsenic trioxide treatment has been implemented for promyelocytic leukemia to target the PML-RARα fusion protein.
|
28521962 |
2018 |
|
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
We hypothesize a novel mechanism of EZH2 function alteration, which may be responsible for an acute myeloid leukemia with APL-like phenotype featuring dysregulation of the RARA and RARG genes.
|
29530751 |
2018 |
|
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Identifying and targeting oncogenic fusion genes have revolutionized the treatment of leukemia, such as PML-RARα fusion gene in acute promyelocytic leukemia.
|
30179602 |
2018 |
|
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
We present a case of an 18-year-old female who was diagnosed with AML (FLT3 (Fms like tyrosine kinase 3) and PML-RARA (promyelocytic leukemia-retinoic acid receptor alpha) translocation-negative) and after initial treatment with a standard induction regimen of cytarabine and daunorubicin (3+7 regimen), her bone marrow showed blast cells less than 5% and dense aggregates/sheets of atypical/immature mast cells with immunohistochemical stain CD117+ve and toluidine blue positive in mast cell aggregates.
|
30800544 |
2018 |
|
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
To understand the relationship between PML/RARα and the oncogene in the development of APL, we investigate the regulation mechanism of PML/RARα to MYB proto-oncogene and the role of this regulation on the proliferation and differentiation of APL cells.
|
30335887 |
2018 |
|
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
PML-RARα perturbs the normal epigenetic setting, which is essential to oncogenic transformation in acute promyelocytic leukemia (APL).
|
29159499 |
2018 |
|
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The As2O3-mediated degradation of PML-RARA (promyelocytic leukemia-retinoic acid receptor-α) oncoprotein via the proteasome pathway appears to be critical for such distinguished sensitivity.
|
30338810 |
2018 |
|
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Acute promyelocytic leukemia (APL) is characterized by the reciprocal translocation t(15;17)(q22;q21), resulting in the fusion of the promyelocytic leukemia gene at 15q22 with the retinoic acid receptor α at 17q21.
|
30344754 |
2018 |
|
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Acute promyelocytic leukemia (APL) is a rare leukemia characterized by the balanced reciprocal translocation between the promyelocytic leukemia gene on chromosome 15 and the retinoic acid receptor α (RARα) gene on chromosome 17, and accounts for 10-15% of newly diagnosed acute myeloid leukemia each year.
|
29541170 |
2018 |
|
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Subsequent OTI sequences were derived from the observed APL breakpoint between PML and RARA.
|
29447373 |
2018 |