|
Cardiotoxicity
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer.
|
26237429 |
2015 |
|
Malignant neoplasm of breast
|
0.330 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Schizophrenia
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.
|
31374203 |
2019 |
|
Malignant Childhood Neoplasm
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer.
|
26237429 |
2015 |
|
Malignant Childhood Neoplasm
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer.
|
26237429 |
2015 |
|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.
|
31374203 |
2019 |
|
Vital capacity
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Critical role of retinoid/rexinoid signaling in mediating transformation and therapeutic response of NUP98-RARG leukemia.
|
25510432 |
2015 |
|
leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
RARA and RARG gene downregulation associated with EZH2 mutation in acute promyelocytic-like morphology leukemia.
|
29530751 |
2018 |
|
Acute Promyelocytic Leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We hypothesize a novel mechanism of EZH2 function alteration, which may be responsible for an acute myeloid leukemia with APL-like phenotype featuring dysregulation of the RARA and RARG genes.
|
29530751 |
2018 |
|
Childhood Leukemia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Critical role of retinoid/rexinoid signaling in mediating transformation and therapeutic response of NUP98-RARG leukemia.
|
25510432 |
2015 |
|
Childhood Leukemia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
RARA and RARG gene downregulation associated with EZH2 mutation in acute promyelocytic-like morphology leukemia.
|
29530751 |
2018 |
|
Fibrodysplasia Ossificans Progressiva
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In addition, an RAR-γ agonist blocked heterotopic ossification in transgenic mice expressing activin receptor-like kinase-2 (ALK2) Q207D, a constitutively active form of the receptor that is related to ALK2 R206H found in individuals with fibrodysplasia ossificans progressiva.
|
21460849 |
2011 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Currently, pharmacogenomic testing of all childhood cancer patients with an indication for doxorubicin or daunorubicin therapy for RARG rs2229774, SLC28A3 rs7853758, and UGT1A6*4 rs17863783 variants is recommended.
|
29713898 |
2018 |
|
Keratoderma, Palmoplantar
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We have examined two families with this type of palmoplantar keratoderma and localized the causative genetic defect to a 14 cM interval on chromosome 12q11-q13, a region known to contain the keratin type II gene cluster as well as the retinoic acid receptor gamma gene.
|
7531539 |
1994 |
|
Cardiotoxicity
|
0.400 |
Biomarker
|
disease |
CTD_human |
A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer.
|
26237429 |
2015 |
|
Malignant neoplasm of breast
|
0.330 |
Biomarker
|
disease |
BEFREE |
Potential role for retinoic acid receptor-gamma in the inhibition of breast cancer cells by selective retinoids and interferons.
|
8603404 |
1996 |
|
Cleft Palate
|
0.300 |
Biomarker
|
disease |
CTD_human |
Retinoic acid drives aryl hydrocarbon receptor expression and is instrumental to dioxin-induced toxicity during palate development.
|
21807577 |
2011 |
|
Heart Diseases
|
0.300 |
Biomarker
|
group |
CTD_human |
A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer.
|
26237429 |
2015 |
|
Congenital musculoskeletal anomalies
|
0.300 |
Biomarker
|
group |
CTD_human |
Contribution of retinoic acid receptor gamma to retinoid-induced craniofacial and axial defects.
|
9142499 |
1997 |
|
Cleft palate, isolated
|
0.300 |
Biomarker
|
disease |
CTD_human |
Retinoic acid drives aryl hydrocarbon receptor expression and is instrumental to dioxin-induced toxicity during palate development.
|
21807577 |
2011 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Collectively, our results defined RARγ as tumor suppressor in colorectal cancer that acts by restricting oncogenic signaling by the Hippo-Yap pathway, with potential implications for new approaches to colorectal cancer therapy.
|
27325643 |
2016 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
We recently demonstrated that retinoic acid receptor-γ (RARγ) is overexpressed and acts as a tumor promoter in hepatocellular carcinoma (HCC).
|
28336971 |
2017 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
In addition, some genes were up-regulated, including matrix metalloproteinse 2(MMP-2), MMP-16(MT3-MMP), SKY, CD9 and semaphorin V. A number of genes were down-regulated, including neuroendocrine-dlg (NE-dlg), retinoic acid receptor gamma and tumor suppressor DCC colorectal.
|
12174360 |
2002 |
|
leukemia
|
0.040 |
Biomarker
|
disease |
LHGDN |
A redundant oncogenic potential of the retinoic receptor (RAR) alpha, beta and gamma isoforms in acute promyelocytic leukemia.
|
17252005 |
2007 |