|
Acute Erythroblastic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our study is the first to report that treatment with a RARγ specific agonist augments cellular adhesion to α5β1 integrin substrates, increases cell surface levels of the β1 integrin subunit, and dampens cellular proliferation in a time and concentration dependent manner in a human erythroleukemia cell line.
|
28552962 |
2017 |
|
Acute leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
While the nucleoporin 98-retinoic acid receptor gamma (NUP98-RARG) is the first RARG fusion protein found in acute leukemia, its roles and the molecular basis in oncogenic transformation are currently unknown.
|
25510432 |
2015 |
|
Acute Promyelocytic Leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We hypothesize a novel mechanism of EZH2 function alteration, which may be responsible for an acute myeloid leukemia with APL-like phenotype featuring dysregulation of the RARA and RARG genes.
|
29530751 |
2018 |
|
Acute Promyelocytic Leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
These uncovered fusion genes strongly suggested their contributions to leukemogenesis as driver alternations and APL phenotype may arise by abnormalities of other members of the nuclear receptor superfamily involved in retinoid signaling (RARB or RARG) or even by mechanisms distinct from the formation of aberrant retinoid receptors.
|
30575821 |
2019 |
|
Acute Promyelocytic Leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
A novel NUP98/RARG gene fusion in acute myeloid leukemia resembling acute promyelocytic leukemia.
|
20935257 |
2011 |
|
Acute Promyelocytic Leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
RARG fusion is rare but recurrent in APL, further investigation in larger cohorts is expected to assess frequency, clinical characteristics and outcomes of RARG-translocation in APL.
|
30996344 |
2019 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Retinoic acid receptor-alpha messenger RNA expression is increased and retinoic acid receptor-gamma expression is decreased in Barrett's intestinal metaplasia, dysplasia, adenocarcinoma sequence.
|
11231454 |
2001 |
|
Adult Erythroleukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our study is the first to report that treatment with a RARγ specific agonist augments cellular adhesion to α5β1 integrin substrates, increases cell surface levels of the β1 integrin subunit, and dampens cellular proliferation in a time and concentration dependent manner in a human erythroleukemia cell line.
|
28552962 |
2017 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We described applications that show how investigating the behaviour of FFLs in glioblastoma can reveal FFLs (such as RARG-NR1I2-CDX2) that are associated with prognosis.
|
26526635 |
2015 |
|
Autoimmune thyroiditis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A similar effect of AIT was observed with a decrease in RARγ expression in PTC/AIT+ patients.
|
31579073 |
2019 |
|
B-Cell Lymphomas
|
0.010 |
Biomarker
|
group |
BEFREE |
Here we investigated the novel BH3 domain mimetic, JY-1-106, which antagonizes the anti-apoptotic BCL-2 family members B-cell lymphoma-extra large (BCL-xL) and myeloid cell leukemia-1 (MCL-1) alone and in combination with retinoids including atRA, AM580 (RARα agonist), and SR11253 (RARγ antagonist).
|
25088254 |
2014 |
|
Bile duct carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the role of RARγ in cholangiocarcinoma (CCA), chemoresistant bile duct carcinoma with a poor prognosis, remains unclear.
|
23798555 |
2013 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The functional consequence of the interplay between c-Myc oncogene expression and the RARγ to RARα/β balance suggests that prevalence of RARγ over-RARα/β expression levels in breast cancer accompanied by c-Myc amplification or over-expression in breast cancer should be predictive of response to treatment with RARα-isotype-specific agonists and warrant monitoring during clinical trials.
|
22920668 |
2012 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Pre-clinical observation highlighted that triple negative (estrogen receptor/progesterone receptor/human epidermal growth factor receptor)-breast cancer cells displayed resistance to retinoids due to the RARγ high expression profile.
|
29849791 |
2018 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Potential role for retinoic acid receptor-gamma in the inhibition of breast cancer cells by selective retinoids and interferons.
|
8603404 |
1996 |
|
Carcinogenesis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Reversal by RARα agonist Am580 of c-Myc-induced imbalance in RARα/RARγ expression during MMTV-Myc tumorigenesis.
|
22920668 |
2012 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Here, we identify the nuclear receptor RARγ as a regulator of the Hippo-Yap pathway in colorectal tumorigenesis and metastasis.
|
27325643 |
2016 |
|
Cardiotoxicity
|
0.400 |
Biomarker
|
disease |
CTD_human |
A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer.
|
26237429 |
2015 |
|
Cardiotoxicity
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer.
|
26237429 |
2015 |
|
Cartilaginous exostosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Palovarotene, an agonist of nuclear retinoic acid receptor gamma (RARγ) has shown therapeutic actions for heterotopic ossification and osteochondroma without serious adverse effects in animal models.
|
31808569 |
2019 |
|
Central neuroblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We, firstly, examined primary NB tumor tissue for a correlation between endogenous RAR gamma expression and clinical stage of the tumor and secondly, the effects of exogenous over-expression of the RAR gamma gene on a human NB tumor cell line.
|
7630632 |
1995 |
|
Central neuroblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found that retinoic acid receptor gamma (RARG) expression was decreased, whereas miR-124 expression was increased during neural differentiation in mouse Neuroblastoma (N2a) Cells, P19 embryonal carcinoma (P19) cells, and mouse brain, as detected by immunoblotting or RT-qPCR.
|
31170403 |
2020 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Currently, pharmacogenomic testing of all childhood cancer patients with an indication for doxorubicin or daunorubicin therapy for RARG rs2229774, SLC28A3 rs7853758, and UGT1A6*4 rs17863783 variants is recommended.
|
29713898 |
2018 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We described applications that show how investigating the behaviour of FFLs in glioblastoma can reveal FFLs (such as RARG-NR1I2-CDX2) that are associated with prognosis.
|
26526635 |
2015 |
|
Childhood Leukemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
The regulation of the subcellular content of CDK1 and RARγ by ATRA is an important process for achieving an effective response in treatment of leukemia.
|
23518499 |
2013 |