Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Specifically, we demonstrate that DRH-1/RIG-I is required for inducing the IPR in response to Orsay virus infection, but not in response to other triggers like microsporidian infection or proteotoxic stress.
|
31619561 |
2020 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results show that the small RIG-I activator 3p10LG9 can confer short-term protection against DENV and can be further explored as an antiviral treatment in humans.<b>IMPORTANCE</b> Short hairpin RNA ligands that activate RIG-I induce antiviral responses in infected cells and prevent or control viral infections.
|
31043531 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
A better understanding of RIG-I sensing of IAV infection provides insight into the development of novel interventions to combat influenza virus infection.
|
30602605 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
However, little is known about the biological behaviors of Rig-I devoid of viral infection.
|
31595820 |
2019 |
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of the pathogen-associated molecular patterns (PAMPs) in the form of viral double-stranded RNA (dsRNA) motifs to induce expression of type 1 interferons (IFN1) (IFNα and IFNβ) and other pro-inflammatory cytokines during the early stage of viral infection.
|
31379819 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Mechanistically, Lnczc3h7a binds to both TRIM25 and activated RIG-I, serving as a molecular scaffold for stabilization of the RIG-I-TRIM25 complex at the early stage of viral infection.
|
31036902 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
DHX15 associates with RIG-I caspase activation and recruitment domains (CARDs) through its amino terminus, in which the complex is recruited to MAVS on virus infection.
|
31090472 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Previously, PFAS has been reported to modulate RIG-I activation during viral infection via deamidation.
|
30987822 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Upon virus infection, ZNFX1 immediately recognizes viral RNA through its Armadillo-type fold and P-loop domain and then interacts with mitochondrial antiviral signalling protein to initiate the type I IFN response without depending on retinoic acid-inducible gene I-like receptors (RLRs).
|
31685995 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Neuronal transcriptomic responses to Japanese encephalitis virus infection with a special focus on chemokine CXCL11 and pattern recognition receptors RIG-1 and MDA5.
|
30481615 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
RIG-I is a cytosolic RNA sensor that recognizes short 5' triphosphate RNA, commonly generated during virus infection.
|
31463653 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
We found that intracellular poly(I·C) transfection to mimic viral infection enhances the RIG-I/MDA5 (melanoma differentiation-associated gene 5)-mediated dimerization of interferon regulatory factor 3 (IRF-3).
|
29496994 |
2018 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Several reports indicate that Toll-like receptor (TLR) stimulation of DCs is accompanied by a rapid induction of glycolysis; however, the metabolic requirements of retinoic-acid inducible gene I (RIG-I)-like receptor (RLR) activation have not defined either in conventional DCs (cDCs) or in plasmacytoid DCs (pDCs) that are the major producers of type I interferons (IFN) upon viral infections.
|
30622542 |
2018 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Defective RNA sensing by RIG-I in severe influenza virus infection.
|
29453856 |
2018 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest that PACT plays an important role in potentiating RIG-I function to produce type I IFNs in order to restrict arenavirus replication and that viral NP RNase activity is essential for optimal viral replication by suppressing PACT-induced RIG-I activation.<b>IMPORTANCE</b> We report here a new role of the nucleoproteins of arenaviruses that can block type I IFN production via their specific inhibition of the cellular protein sensors of virus infection (RIG-I and PACT).
|
29669840 |
2018 |
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
While SDD-AGE analysis of whole cell extracts revealed the formation of previously described high molecular weight prion-like aggregates upon constitutively active RIG-I ectopic expression and virus infection, non-reducing SDS-PAGE allowed us to demonstrate the induction of lower molecular weight oligomers.
|
29385716 |
2018 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), including RIG-I, melanoma-differentiation-associated gene 5 (MDA5), and LGP2, function as cytoplasmic virus sensor proteins during viral infection.
|
29939295 |
2018 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Retinoic acid-inducible gene I (RIG-I), a cytosolic RNA helicase sensor, plays a significant role in the induction of type I interferon responses following viral infection.
|
29970461 |
2018 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The RNA binding protein La/SS-B promotes RIG-I-mediated type I and type III IFN responses following Sendai viral infection.
|
29109527 |
2017 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Retinoic acid-inducible gene I (RIG-I) is an important regulator of virus-induced antiviral interferons (IFNs) and proinflammatory cytokines which participate in clearing viral infections.
|
28865477 |
2017 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Further analyses indicated that depletion of H-Ras results in a robust increase in vesicular stomatitis virus infection and a decrease in Sendai virus (SeV)-induced retinoic acid-inducible gene-I-like receptor (RLR) signaling.
|
28848563 |
2017 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
A recent study found that the delivery of circRNAs generated <i>in vitro</i> activates RIG-I-mediated innate immune responses and provides protection against viral infection.
|
29230098 |
2017 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection.
|
28760668 |
2017 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Sumoylation of the caspase recruitment domains of MDA5 and RIG-I is also required for their dephosphorylation by PP1 and activation upon viral infection.
|
28250012 |
2017 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Two cytosolic RIG-like RNA helicases, RIG-I and MDA5, are key to type I interferon (IFN) induction in response to viral infection.
|
26939124 |
2016 |