RB1, RB transcriptional corepressor 1, 5925

N. diseases: 339; N. variants: 239
Disease: Merkel cell carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007129
Disease: Merkel cell carcinoma
Merkel cell carcinoma 		0.030 AlteredExpression disease BEFREE Cutaneous neuroendocrine (Merkel cell) carcinoma most often arises de novo in the background of a clonally integrated virus, the Merkel cell polyomavirus, and is notable for positive expression of retinoblastoma 1 (RB1) protein and low expression of p53 compared with the rare Merkel cell polyomavirus-negative Merkel cell carcinomas. 26022453 2015
CUI: C0007129
Disease: Merkel cell carcinoma
Merkel cell carcinoma 		0.030 Biomarker disease BEFREE RB1 gene in Merkel cell carcinoma: hypermethylation in all tumors and concurrent heterozygous deletions in the polyomavirus-negative subgroup. 24735260 2014
CUI: C0007129
Disease: Merkel cell carcinoma
Merkel cell carcinoma 		0.030 Biomarker disease BEFREE The RB1 protein was not detected by Western blot analysis in any of nine MCC cell lines tested. 9290960 1997