Disease: Mesothelioma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025500
Disease: Mesothelioma
Mesothelioma 		0.020 AlteredExpression disease BEFREE We showed that RBL2/p130 and AKT1 physically interact and AKT phosphorylates RBL2/p130 Ser941, located in the pocket domain, but not when this residue is mutated into Ala. We found that pharmacological inhibition of AKT, through the highly selective AKT inhibitor VIII (AKTiVIII), impairs RBL2/p130 Ser941 phosphorylation and increases RBL2/p130 stability, mRNA expression and nuclear levels in both lung cancer and mesothelioma cell lines, mirroring the more extensively studied effects on the p27 cell-cycle inhibitor. 29606701 2018
CUI: C0025500
Disease: Mesothelioma
Mesothelioma 		0.020 Biomarker disease BEFREE It has been reported that Rb2/p130 is involved in the pathogenesis and progression of lung cancer and mesothelioma. 11331952 2001