|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
The expression of genes and proteins involved in the biosynthesis (histidine decarboxylase, HDC), action (histamine receptors: HRH1-HRH4), and metabolism of histamine is largely unknown both in the normal human adrenal cortex and in adrenocortical tumors.
|
19568768 |
2009 |
|
Rheumatoid Arthritis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Histamine and Histamine H4 Receptor Promotes Osteoclastogenesis in Rheumatoid Arthritis.
|
28446753 |
2017 |
|
Rheumatoid Arthritis
|
0.030 |
AlteredExpression
|
disease |
LHGDN |
Expression of histamine H4 receptor in synovial cells from rheumatoid arthritic patients.
|
17978505 |
2007 |
|
Rheumatoid Arthritis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Histamine H4 receptor expression in human synovial cells obtained from patients suffering from rheumatoid arthritis.
|
16204969 |
2005 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
Immunomodulatory role of histamine H4 receptor in breast cancer.
|
29988113 |
2019 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Immunomodulatory role of histamine H4 receptor in breast cancer.
|
29988113 |
2019 |
|
Allergic rhinitis (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
Histamine H4 receptor regulates IL-6 and INF-γ secretion in native monocytes from healthy subjects and patients with allergic rhinitis.
|
31583075 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, these findings reveal that rs11662595 is a loss-of-function polymorphism that results in dysfunction of HRH4 and attenuates the anti-EMT function of HRH4 in NSCLC, which provides a promising biomarker for prognosis and therapy of NSCLC.
|
28847511 |
2017 |
|
Allergic rhinitis (disorder)
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Histamine H4 receptor gene polymorphisms: a potential predictor of oral H1 antihistamine efficacy for allergic rhinitis.
|
27888642 |
2017 |
|
Psoriasis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The analysis of association between HRH4 polymorphisms and psoriasis was assessed by odds ratio with 95% confidence interval.
|
27725312 |
2016 |
|
Non-Small Cell Lung Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In conclusion, these findings revealed the anti-EMT effect of histamine H4 receptor activation in NSCLC, which provide novel insight into the development mechanism of NSCLC; and H4 receptors may be a new therapeutic target for NSCLC treatment.
|
24447834 |
2014 |
|
Malignant neoplasm of breast
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
These findings indicated that the variants of rs623590, rs11662595 and rs1421125 genotypes of HRH4 gene were significantly associated with the risk and malignant degree of breast cancer in Chinese Han populations, which may provide us novel insight into the pathogenesis of breast cancer although further studies with larger participants worldwide are still needed for conclusion validation.
|
23481304 |
2013 |
|
Breast Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
These findings indicated that the variants of rs623590, rs11662595 and rs1421125 genotypes of HRH4 gene were significantly associated with the risk and malignant degree of breast cancer in Chinese Han populations, which may provide us novel insight into the pathogenesis of breast cancer although further studies with larger participants worldwide are still needed for conclusion validation.
|
23481304 |
2013 |
|
Colorectal Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Previously, we reported the decreased expression of HRH4 in colorectal cancers and revealed its correlation with tumor proliferation.
|
22363581 |
2012 |
|
Colorectal Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The protein levels of HRH4 were reduced in most of the human CRC samples regardless of grade or Dukes classification. mRNA levels of HRH4 were also reduced in both early-stage and advanced CRC samples.
|
21609450 |
2011 |
|
Psoriasis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The histamine H4 receptor is highly expressed on plasmacytoid dendritic cells in psoriasis and histamine regulates their cytokine production and migration.
|
21614010 |
2011 |
|
Arthritis
|
0.020 |
Biomarker
|
disease |
BEFREE |
HRH4 amplifications also positively correlated with the incidence of arthritis (P = 0·019, OR 1·96, 95% CI 1·11-3·47), and proteinuria (P < 0·001, OR 2·95, 95% CI 1·73-5·00) and antinuclear antibody abnormalities (P < 0·001, OR 2·97, 95% CI 1·66-5·33).
|
20618322 |
2010 |
|
Colonic Neoplasms
|
0.020 |
GeneticVariation
|
group |
LHGDN |
Decreased expression of histamine H1 and H4 receptors suggests disturbance of local regulation in human colorectal tumours by histamine.
|
18258331 |
2008 |
|
Arthritis
|
0.020 |
Biomarker
|
disease |
LHGDN |
Distribution pattern of histamine H4 receptor in human synovial tissue from patients with rheumatoid arthritis.
|
17806182 |
2007 |
|
Colonic Neoplasms
|
0.020 |
Biomarker
|
group |
LHGDN |
The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer.
|
16203768 |
2005 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Pathophysiological Role of Histamine H4 Receptor in Cancer: Therapeutic Implications.
|
31231212 |
2019 |
|
Malignant neoplasm of skin
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
When searched in The Cancer Genome Atlas (TCGA) database, human H4R gene was found to be expressed in bladder cancer, kidney cancer, breast cancer, gastrointestinal cancers, lung cancer, endometrial cancer, and skin cancer.
|
31231212 |
2019 |
|
Meniere Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These suggested that HRH4 rs77485247 polymorphism may be an important mediator in regulating proinflammatory cytokines, which are involved in the pathogenesis of MD.
|
31133025 |
2019 |
|
Vertigo
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
We selected one SNP, rs77485247 in HRH4 and conducted an exploratory investigation of its correlations with the symptoms of vertigo and proinflammatory cytokines levels in MD patients.
|
31133025 |
2019 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Pathophysiological Role of Histamine H4 Receptor in Cancer: Therapeutic Implications.
|
31231212 |
2019 |