|
Adenocarcinoma
|
0.300 |
Biomarker
|
group |
CTD_human |
Deletion and down-regulation of HRH4 gene in gastric carcinomas: a potential correlation with tumor progression.
|
22363581 |
2012 |
|
Malignant neoplasm of stomach
|
0.300 |
Biomarker
|
disease |
CTD_human |
In vitro studies, using gastric cancer cell lines, showed that the alteration of HRH4 expression on gastric cancer cells influences tumor growth upon exposure to histamine.
|
22363581 |
2012 |
|
Stomach Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Deletion and down-regulation of HRH4 gene in gastric carcinomas: a potential correlation with tumor progression.
|
22363581 |
2012 |
|
Adenocarcinoma, Basal Cell
|
0.300 |
Biomarker
|
disease |
CTD_human |
Deletion and down-regulation of HRH4 gene in gastric carcinomas: a potential correlation with tumor progression.
|
22363581 |
2012 |
|
Adenocarcinoma, Oxyphilic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Deletion and down-regulation of HRH4 gene in gastric carcinomas: a potential correlation with tumor progression.
|
22363581 |
2012 |
|
Carcinoma, Cribriform
|
0.300 |
Biomarker
|
disease |
CTD_human |
Deletion and down-regulation of HRH4 gene in gastric carcinomas: a potential correlation with tumor progression.
|
22363581 |
2012 |
|
Carcinoma, Granular Cell
|
0.300 |
Biomarker
|
disease |
CTD_human |
Deletion and down-regulation of HRH4 gene in gastric carcinomas: a potential correlation with tumor progression.
|
22363581 |
2012 |
|
Adenocarcinoma, Tubular
|
0.300 |
Biomarker
|
disease |
CTD_human |
Deletion and down-regulation of HRH4 gene in gastric carcinomas: a potential correlation with tumor progression.
|
22363581 |
2012 |
|
Hereditary Diffuse Gastric Cancer
|
0.300 |
Biomarker
|
disease |
CTD_human |
Deletion and down-regulation of HRH4 gene in gastric carcinomas: a potential correlation with tumor progression.
|
22363581 |
2012 |
|
Pruritus
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
We have also investigated the effect of histamine H4 receptor antagonists on histamine H1 receptor antagonist-resistant pruritus using a mouse model.
|
19652466 |
2009 |
|
Dermatitis, Atopic
|
0.040 |
Biomarker
|
disease |
BEFREE |
Discovery of a Novel Highly Selective Histamine H4 Receptor Antagonist for the Treatment of Atopic Dermatitis.
|
29579390 |
2018 |
|
Eczema
|
0.040 |
Biomarker
|
disease |
BEFREE |
Discovery of a Novel Highly Selective Histamine H4 Receptor Antagonist for the Treatment of Atopic Dermatitis.
|
29579390 |
2018 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Herein, we investigated the potential role of the histamine receptor H4 (HRH4) as a therapeutic target for LCTs using R2C rat Leydig tumour cells, a well-documented in vitro model for Leydigioma.
|
29367056 |
2018 |
|
Autoimmune Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
The histamine H4 receptor (HRH4) has been shown to be associated with a number of autoimmune disorders, including AD.
|
23517361 |
2013 |
|
Dermatitis, Atopic
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
CNVs of the HRH4 gene are associated with AD in a Chinese population.
|
23517361 |
2013 |
|
Eczema
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
CNVs of the HRH4 gene are associated with AD in a Chinese population.
|
23517361 |
2013 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
In vitro studies, using gastric cancer cell lines, showed that the alteration of HRH4 expression on gastric cancer cells influences tumor growth upon exposure to histamine.
|
22363581 |
2012 |
|
Dermatitis, Atopic
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
In this review, we describe a possible genetic impact on the expression level of the histamine H4 receptor and summarize the current data regarding the activity of the histamine H4 receptor on the key effector cells in atopic dermatitis.
|
21104170 |
2011 |
|
Eczema
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
In this review, we describe a possible genetic impact on the expression level of the histamine H4 receptor and summarize the current data regarding the activity of the histamine H4 receptor on the key effector cells in atopic dermatitis.
|
21104170 |
2011 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Attenuated expression of HRH4 in colorectal carcinomas: a potential influence on tumor growth and progression.
|
21609450 |
2011 |
|
Autoimmune Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
In this review, we enlightened various functions of histamine H(4) and use of histamine H(4) receptor antagonists in autoimmune diseases, allergic responses, inflammatory responses, and in superoxide generation which are helpful to establish H(4) receptor antagonists as newer anti histamines.
|
21175423 |
2010 |
|
Autoimmune Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
Histamine receptor H4 (HRH4) has been shown to be related to different kinds of allergic and autoimmune disorders.
|
20199554 |
2010 |
|
Autoimmune Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
Systemic lupus erythematosus (SLE) is a complex genetic disease; the histamine H4 receptor (HRH4) has been shown to be related to different kinds of autoimmune disorders; and copy number variations (CNVs) have been found to be associated with various types of diseases.
|
20618322 |
2010 |
|
Dermatitis, Atopic
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We found three new single nucleotide polymorphisms (SNPs) in HRH4 which were significantly associated with AD: ss142022671 [odds ratio (OR) 1.87, 95% confidence interval (CI) 1.24-2.81; P = 0.002], ss142022677 (OR 4.40, 95% CI 2.42-8.00; P = 1.5 x 10(-7)) and ss142022679 (OR 4.26, 95% CI 2.38-7.61; P = 1.3 x 10(-7)).
|
20199554 |
2010 |
|
Eczema
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We found three new single nucleotide polymorphisms (SNPs) in HRH4 which were significantly associated with AD: ss142022671 [odds ratio (OR) 1.87, 95% confidence interval (CI) 1.24-2.81; P = 0.002], ss142022677 (OR 4.40, 95% CI 2.42-8.00; P = 1.5 x 10(-7)) and ss142022679 (OR 4.26, 95% CI 2.38-7.61; P = 1.3 x 10(-7)).
|
20199554 |
2010 |