HRH4, histamine receptor H4, 59340

N. diseases: 48; N. variants: 12
Disease: Dermatitis, Atopic ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.040 Biomarker disease BEFREE Discovery of a Novel Highly Selective Histamine H4 Receptor Antagonist for the Treatment of Atopic Dermatitis. 29579390 2018
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.040 GeneticVariation disease BEFREE CNVs of the HRH4 gene are associated with AD in a Chinese population. 23517361 2013
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.040 AlteredExpression disease BEFREE In this review, we describe a possible genetic impact on the expression level of the histamine H4 receptor and summarize the current data regarding the activity of the histamine H4 receptor on the key effector cells in atopic dermatitis. 21104170 2011
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.040 GeneticVariation disease BEFREE We found three new single nucleotide polymorphisms (SNPs) in HRH4 which were significantly associated with AD: ss142022671 [odds ratio (OR) 1.87, 95% confidence interval (CI) 1.24-2.81; P = 0.002], ss142022677 (OR 4.40, 95% CI 2.42-8.00; P = 1.5 x 10(-7)) and ss142022679 (OR 4.26, 95% CI 2.38-7.61; P = 1.3 x 10(-7)). 20199554 2010