RXFP1, relaxin family peptide receptor 1, 59350

N. diseases: 41; N. variants: 1
Disease: Irradiation cystitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0156270
Disease: Irradiation cystitis
Irradiation cystitis 		0.010 AlteredExpression disease BEFREE hRLX2 reversed fibrosis, decreased collagen content, improved bladder wall architecture, and increased bladder compliance, detrusor smooth muscle Cav1.2 expression and detrusor contractility in mice with chronic radiation cystitis. hRLX2 treatment outcomes were likely caused by the activation of RXFP1/2 receptors which are expressed on the detrusor. 29806709 2018