|
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The purpose of this study was to investigate the expression pattern of ZNF703 in HNSCC in association with CCND1 expression and Akt phosphorylation.
|
31574205 |
2019 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings suggest that cyclin D1 plays an important role in tumorigenesis of HNSCC, and gene amplification is not one of the major mechanisms for overexpression of cyclin D1.
|
9310139 |
1997 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings demonstrate that TRUE gene silencing of cyclin D1 leads to inhibition of the growth of HNSCC cells and suggest that these sgRNAs alone or combined with cisplatin may be a useful new therapy for HNSCCs.
|
25437003 |
2014 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Molecular studies of squamous cell carcinoma of the head and neck (HNSCC) have demonstrated multiple genetic abnormalities such as activation of various oncogenes (Ras, Myc, epidermal growth factor receptor, and cyclin D1), tumor suppressor gene inactivation (TP53 and p16), and loss of heterozygosity at numerous chromosomal locations.
|
14729608 |
2004 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Real-time PCR and immunohistochemistry were used to evaluate EZH2 and cyclin D1 expression in 46 HNSCC samples, and the expression levels also were re-evaluated in 124 independent samples by immunohistochemistry.
|
21989926 |
2012 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This study indicates that immunohistochemical assessment of cyclin D1 expression in SCCHN could be a new predictive marker to select a subgroup of patients that will benefit from neoadjuvant chemotherapy.
|
11504311 |
2001 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
While aberrant expression of cyclin-dependent kinase-4 (CDK4) has been found in squamous cell carcinoma of the head and neck (SCCHN), the associations between CDK4 and its regulators, namely, cyclin D1, cyclin E, gankyrin, SEI1, and BMI1 in gene expression remain to be explored.
|
24982332 |
2014 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
In a population-based case-control study of 698 cases and 777 controls, we both genotyped all participants for the CCND1 gene and did immunohistochemical staining of the cyclin D1 protein in the HNSCC tumors.
|
18413827 |
2008 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In Series 1, overexpression of cyclin D1 and 11q13 rearrangements, assessed by immunohistochemistry and cytogenetics, respectively, were compared with clinical data in 75 patients with SCCHN.
|
9010112 |
1997 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cyclin D1 was silenced in an HNSCC cell line and its effect tested in sensitizing the cells to cisplatin, in vitro as well as in vivo.
|
22213296 |
2012 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In a xenograft model of squamous cell carcinoma of the head and neck (SCCHN), daily administration of the STAT3 decoy (25 microg) resulted in decreased tumor volumes, abrogation of STAT3 activation, and decreased expression of STAT3 target genes (VEGF, Bcl-xL, and cyclin D1) compared to treatment with a mutant control decoy.
|
15592503 |
2005 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
PRAD-1 (CCND1)/cyclin D1 oncogene amplification in primary head and neck squamous cell carcinoma.
|
8004570 |
1994 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest the prognostic value of CCND1 amplification and cyclin D1 expression for patients with OSCC and highlight the genetic differences in HNSCC of different subanatomic localisation.
|
23494454 |
2014 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
On transduction of the human HNSCC cell line with adenovirus-p27 (Ad-p27), a high level of p27 expression and increase of cyclin D1 and E were observed.
|
12478543 |
2003 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In the present study, 32 squamous cell carcinoma of the head and neck (SCCHN) were investigated regarding chromosomal abnormalities involving 11q13 by cytogenetic analysis, genomic CCND1 amplification by differential PCR and FISH, and cyclin D1 expression on the mRNA and protein level by differential RT-PCR and immunohistochemistry, respectively.
|
11743641 |
2002 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cyclin D1, a cell cycle regulator localized to chromosome 11q13, is amplified in several human tumors including head and neck squamous cell carcinoma (HNSCC).
|
12148857 |
2002 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
CTD_human |
This was verified by IHC staining of CCND1 from HNSCC patients.
|
29464035 |
2018 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have now examined the association of this and a second CCND1 polymorphism with gene expression and outcome in SCCHN patients.
|
11696452 |
2001 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
Subsequent mRNA expression analysis of 11q13 candidate genes CCND1 and CTTN revealed that HNSCC cell lines exhibiting a DNA copy number gain on 11q13 had a higher transcript level of CCND1 and CTTN compared with HNSCC cell lines without 11q13 copy number gain (P = 0.014 and P = 0.009, respectively).
|
20149059 |
2010 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
Abrogation of cyclin D1 action through antisense cyclin D1 shows promise as an antitumor therapy, with an inhibitory effect in head and neck squamous cell carcinoma both in vitro and in vivo.
|
11404608 |
2001 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma.
|
12067972 |
2002 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
Detection of CCND1 amplification using FISH may be a useful marker of sensitivity to NAC and chemoradiotherapy for HNSCC.
|
14981992 |
2004 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Amplification of the cyclin D1 gene has been identified in 17-55% of head and neck squamous cell carcinoma.
|
11287281 |
2001 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data indicate that EMS1 amplification, but not CCND1 amplification, predicts early recurrence and reduced survival in squamous cell carcinoma of the head and neck.
|
10955801 |
2000 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism within the cyclin D1 gene is associated with prognosis in patients with squamous cell carcinoma of the head and neck.
|
9796972 |
1998 |