Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
The above Notch signaling proteins showed their synergistic role in modulating Cyclin D1 which in-turn regulates HPV-16 associated ADC of the uterine cervix (UC), affecting women's global health.
|
30903019 |
2019 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Overall, in contrast to gene amplification, which occurred at a frequency of 4.8% (1,419 of 28,769 cases), CCND1 mutations were of very low frequency (0.5%, 151 of 29,432 cases) across all cancers, but were predominantly enriched in uterine endometrioid-type adenocarcinoma (6.5%, 30 of 458 cases) in both primary tumors and in advanced, metastatic endometrial cancer samples.
|
29969496 |
2018 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The prognostic significance of CCND1 protein expression was evaluated by western blot analysis of 32 matched specimens of gastric adenocarcinomas and normal tissues obtained from patients treated at the National Cheng Kung University Hospital (Tainan, Taiwan).
|
28943959 |
2017 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Squamous cell carcinomas showed frequent genomic amplifications of CCND1 and SOX2 and/or TP63, whereas ERBB2, VEGFA and GATA4 and GATA6 were more commonly amplified in adenocarcinomas.
|
28052061 |
2017 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
These results indicate that NKX2-1 directly and positively regulates transcription of <i>cyclin D1</i> Finally, expression of NKX2-1, but not cyclin D1, was significantly associated with metastatic incidence as an independent good prognostic factor of adenocarcinoma.<b>Implications:</b> NKX2-1-expressing adenocarcinomas, whereas NKX2-1 promoted cyclin D1 expression, may show good prognosis features by the metastasis inhibition potency of NKX2-1 regardless cyclin D1 expression.<i></i>.
|
28634225 |
2017 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Overexpression of β-catenin and cyclin D1 was significantly associated with poor overall survival (p = 0.003 and p = 0.0009, respectively; log rank test) in squamous cell carcinomas, not in adenocarcinomas.
|
27498289 |
2016 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Cyclin D1 loss identifies prostate tumors with small-cell differentiation and may identify a small subset of adenocarcinomas with poor prognosis.
|
26246306 |
2015 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Amongst the four proteins, only cyclin D1 overexpression was significantly associated with poor recurrence-free survival (adjusted hazard ratio = 1.87; 95 % confidence interval = 1.12 - 2.69, P = 0.02) in adenocarcinoma but not in squamous cell carcinoma (P = 0.44).
|
26681199 |
2015 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
CTD_human |
PIAS3, SHP2 and SOCS3 Expression patterns in Cervical Cancers: Relevance with activation and resveratrol-caused inactivation of STAT3 signaling.
|
26432044 |
2015 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Further evaluations indicated that phospho-Stat3, phospho-Akt, phospho-nuclear factor κB, cyclin D1, and Ki67 were upregulated in adenocarcinomas from ARR(2)Pb.Stat3C x PTEN(+/-) mice.
|
21390188 |
2011 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Expression of PPARβ/δ mRNA and protein was lower and expression of CYCLIN D1 protein higher in human colon adenocarcinomas compared to matched non-transformed tissue.
|
21400612 |
2011 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We didn't reveal differences in cyclin D1 and galectin-3 expression in SCC and adenocarcinoma patients.
|
22024187 |
2011 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
First, relative expression of both cyclin D1 isoforms was determined in prostate adenocarcinomas.
|
19706803 |
2009 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Association between CCND1 G/A870 polymorphism, allele-specific amplification, cyclin D1 expression, and survival in esophageal and lung carcinoma.
|
19047108 |
2008 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The CCND1/GAPDH mRNA levels were significantly higher in adenocarcinoma (35.125 +/- 37.387) than in non-adenocarcinoma (15.2 +/- 24.699; P = .0158), and CCND1/GAPDH mRNA levels were not significantly different among smoking status, sex, or pathologic stage.
|
17922974 |
2007 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Simultaneous deregulation of p16 and cyclin D1 genes in pancreatic ductal adenocarcinoma: a combined immunohistochemistry and image analysis study based on tissue microarrays.
|
17600882 |
2007 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
LHGDN |
CCND1, EMS1, PIK3CA, and ERBB1 amplifications are uncommon and appear to be late events in the development of ethmoid sinus adenocarcinoma.
|
16815198 |
2006 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Cyclin D1 protein expression was checked in the same group of adenocarcinoma cases.
|
15993030 |
2005 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Using PCR based restriction fragment length polymorphism and single strand conformational polymorphism, we determined single nucleotide exchanges in the p16 and cyclin D1 genes among 56 esophageal adenocarcinomas (ADC) arising in Barrett's esophagus, 95 cardiac gastric ADC, and in 191 distal gastric ADC.
|
16163549 |
2005 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Proteins of cyclin D1 were detected by immunohistochemistry in 42 cases of advanced gastric carcinoma with their follow-up data available, 27 cases of early stage carcinoma, 21 cases of gastric adenoma, 22 cases of hyperplastic polyp and 20 cases of normal mucosa adjacent to adenocarcinomas.
|
15378768 |
2004 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Gastrin-induced gastric adenocarcinoma growth is mediated through cyclin D1.
|
12606305 |
2003 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Increased copy number of the ERBB2 (1 of 22), GATA4 (1 of 22), KRAS (2 of 22), C-MYC (1 of 22), CCNE1 (2 of 22), and CCND1 (2 of 22) genes was also observed in one or more Barrett's adenocarcinomas with HGD.
|
14581353 |
2003 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Cyclin D1 overexpression was found to be present in only 42% of colorectal adenocarcinomas.
|
14592662 |
2003 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin.
|
12209953 |
2002 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin.
|
12209953 |
2002 |