|
Renal Cell Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
6-Gingerol induces cell-cycle G1-phase arrest through AKT-GSK 3β-cyclin D1 pathway in renal-cell carcinoma.
|
31832810 |
2020 |
|
Renal Cell Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Results demonstrated that cyclin D1 overexpression in RCC showed significant favorable prognostic impact on disease-free survival (DFS) (HR 0.57, 95% CI: 0.43-0.74) and disease-specific survival (DSS) (HR 0.59, 95% CI 0.41-0.85) without significant heterogeneity.
|
31748879 |
2019 |
|
Renal Cell Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Cyclin D1 and p57 expression in relation to clinicopathological characteristics and overall survival in patients with renal cell carcinoma.
|
30941985 |
2019 |
|
Renal Cell Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These results suggested that these CCND1 polymorphisms rs1944129 and rs7177 might contribute to the susceptibility of RCC in the Chinese population.
|
29113352 |
2017 |
|
Renal Cell Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Statistical analysis determined the association of CCND1 expression with RCC.
|
27766950 |
2016 |
|
Renal Cell Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
The effect of downregulation of tNASP by siRNA on cell colony formation and proliferation was examined by colony formation assay and CCK-8 assay, cell cycle was analyzed by flow cytometry, and the expression of cyclin D1 and P21 were detected by Western blotting.ERK/MAPK signaling was also analyzed. tNASP has a relative high expression level in human RCC tissues.
|
25669170 |
2015 |
|
Renal Cell Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
A specific PPARα antagonist, GW6471, induced both apoptosis and cell cycle arrest at G0/G1 in VHL(+) and VHL(-) RCC cell lines (786-O and Caki-1) associated with attenuation of the cell cycle regulatory proteins c-Myc, Cyclin D1, and CDK4; this data was confirmed as specific to PPARα antagonism by siRNA methods.
|
23951092 |
2013 |
|
Renal Cell Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Our results suggest for the first time that let-7a acts as a tumor suppressor in RCC cell lines by down-regulating c-myc and c-myc target genes such as proliferating cell nuclear antigen (PCNA), cyclin D1 (CCND1) and the miR17-92 cluster, which is accompanied by proliferation inhibition and cell cycle arrest.
|
22155254 |
2012 |
|
Renal Cell Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
cAMP-dependent cytosolic mislocalization of p27(kip)-cyclin D1 during quinol-thioether-induced tuberous sclerosis renal cell carcinoma.
|
21693435 |
2011 |
|
Renal Cell Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
We evaluated a series of 63 renal oncocytomas and 36 chromophobe renal cell carcinomas and assessed the clinical features, cyclin D1 overexpression by immunohistochemistry, and alterations of the CCND1 gene by fluorescence in situ hybridization.
|
19386349 |
2009 |
|
Renal Cell Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
We observed in the TFE3-positive carcinoma an intense immunoreaction for p21 ((wafl/cip1)), cyclin D1, and cyclin D3, without expression for p53, p16, p27(kip1), and mdm2, whereas the immunoexpression profile observed in the classic RCC was similar to that of clear cell, adult-type RCC.
|
19246164 |
2009 |
|
Renal Cell Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
The combined overexpression of p21, cyclin D1, and cyclin D3 was found exclusively in this type but not in other, more common types of renal carcinoma/oncocytoma (n=27).
|
18358634 |
2008 |
|
Renal Cell Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that VHL inactivation leads to preferential HIF-2 activation and CCND1 expression as described previously in VHL-defective renal cell carcinoma cell lines but not in other cell types.
|
16954163 |
2006 |
|
Renal Cell Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Renal cell carcinomas (RCCs) of the clear cell type are associated with alteration of the von Hippel-Lindau (VHL) tumour suppressor gene as well as subsequent stabilization and over-expression of hypoxia inducible factor (HIF), which causes up-regulation of cyclin D1.
|
15991006 |
2005 |
|
Renal Cell Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
More extensive and larger studies are required to clarify whether the CCND1 genotype is more specifically involved in the onset of a histological subset of RCC or RCC at a younger age.
|
15538282 |
2004 |
|
Renal Cell Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
To test this hypothesis, we investigated TCF-4 splicing isoforms, beta-catenin, and Wnt signal pathway (cyclin D1, c-myc, c-jun, and MMP7) in three RCC cell lines (A498, Caki-1, and Caki-2), 38 primary RCCs, and 29 normal kidney samples.
|
12796377 |
2003 |
|
Renal Cell Carcinoma
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|