|
Lymphoma, Non-Hodgkin
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Mantle cell lymphoma (MCL) is a unique type of non-Hodgkin lymphoma characterized by the overexpression of cyclin D1.
|
30967367 |
2019 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mantle cell lymphoma (MCL), an aggressive subtype of non-Hodgkin lymphoma, is characterized by the hallmark translocation t(11;14)(q13;q32) and the resulting overexpression of cyclin D1 (CCND1).
|
22210878 |
2012 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mantle cell lymphoma (MCL) is a distinct subentity of non-Hodgkin lymphoma, characterized by the chromosomal translocation t(11;14)(q13;q32) leading to an overexpression of cyclin D1 in virtually all cases.
|
19137297 |
2009 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
Biomarker
|
disease |
BEFREE |
Each gene (DLC-1, PCDHGB7, CYP27B1, EFNA5, CCND1 and RARbeta2) was frequently hypermethylated in these NHLs (87, 78, 61, 53, 40 and 38%, respectively), but not in benign follicular hyperplasia.
|
16774933 |
2007 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
As CCND1 expression indicates poor NHL prognosis, our results, if true, would support its potentially dual importance in NHL etiology and survival.
|
16783567 |
2006 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Also, cyclin D1 over expression is associated with poor outcome of NHL patients.
|
17607588 |
2006 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
As CCND1 expression indicates poor NHL prognosis, our results, if true, would support its potentially dual importance in NHL etiology and survival.
|
16783567 |
2006 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
At each anatomic site, MCL cases had higher cyclin D1 levels than other types of NHL or nonneoplastic specimens, without overlap.
|
12011261 |
2002 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mantle cell lymphoma represent a clinicopathologically distinct entity of malignant non-Hodgkin's lymphoma (NHL) and are characterized by a specific chromosomal translocation t(11;14)(q13;q32) involving the cyclin D1 gene also designated as bcl-1/PRAD1 gene on chromosome 11 and the heavy chain immunoglobulin joining region on chromosome 14.
|
9766510 |
1998 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, in another series of 11 patients and a NHL cell line, we demonstrated t(14;18) and t(11;14) in interphase and metaphase cells with a combination of BCL2 (or PRAD1) with IgH gene probes.
|
9209369 |
1997 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The t(11;14)(q13;q32) translocation, which juxtaposes the BCL1 oncogene with the Ig heavy chain locus, has been associated with an uncommon subtype of non-Hodgkin's lymphoma (NHL) termed mantle cell lymphoma (MCL).
|
7579380 |
1995 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly these fragile sites were located in the same chromosomal bands as the oncogenes, MOS, MYC, BCL-1 and BCL-2 as well as cancer breakpoints specifically associated with non-Hodgkin's lymphoma, suggesting the possibility that fragile sites may play a critical role in the pathogenesis of non-Hodgkin's lymphoma.
|
7954347 |
1994 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We investigated rearrangements of the bcl-1 and bcl-2 protooncogenes in 13 cases of B lineage diffuse small cleaved-cell lymphoma (DSCL), and correlated the results with clinical history, immunophenotype, and outcome.
|
7981893 |
1994 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Cyclin D1 overexpression in non-Hodgkin's lymphoma with chromosome 11 bcl-1 rearrangement.
|
8172823 |
1994 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Twenty-nine cases of non-Hodgkin's lymphoma of low-grade malignancy in a European population were investigated for the presence of bcl-2 and bcl-1 gene rearrangement.
|
1757070 |
1991 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, bcl-1 rearrangement occurred at MTC or p94PS in 12 of 23 centrocytic lymphomas (52%), confirming a nonrandom association and suggesting a pathogenetic role for the bcl-1 locus in this immunohistologic subtype of NHL.
|
2070085 |
1991 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The BCL1 locus was rearranged in 9 out of 25 (36%) cases of intermediate lymphocytic cell lymphomas (ILL), in 1 out of 8 cases of diffuse small cleaved cell lymphoma, in 1 out of 12 cases of diffuse mixed cell lymphoma, and in 1 out of 21 cases of diffuse large cell lymphoma.
|
2078513 |
1990 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We studied the molecular structure of the BCL-1 gene in eight B-cell NHL tumors that exhibited a break at 11q13.
|
2787901 |
1989 |