|
Parathyroid Adenoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
So, promoter hypermethylation is associated with down-regulation of CCND1 regulatory genes in sporadic parathyroid adenomas.
|
28600574 |
2017 |
|
Parathyroid Adenoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
DNA translocations with cyclin D1 overexpression occur in PAs (8%).
|
27071708 |
2016 |
|
Parathyroid Adenoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Forty-one parathyroid adenomas from patients with symptomatic PHPT and ten normal parathyroid glands either from patients with PHPT (n=3) or from euthyroid patients without PHPT during thyroid surgery (n=7) were analyzed for vitamin D receptor (VDR), calcium-sensing receptor (CASR), cyclin D1 (CD1), and parathyroid hormone (PTH) expressions.
|
23660642 |
2013 |
|
Parathyroid Adenoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The possible role of cyclin-dependent kinase inhibitor (CDKI) genes was raised by recognition of cyclin D1 as a parathyroid oncogene, identification of rare germline mutations in CDKI genes in patients with multiple endocrine neoplasia type 1; that in rodents, mutation in Cdkn1b caused parathyroid tumors; and subsequently through identification of rare predisposing germline sequence variants and somatic mutation of CDKN1B, encoding p27(kip1), in sporadic human parathyroid adenoma.
|
23715670 |
2013 |
|
Parathyroid Adenoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic abnormalities, such as those of multiple endocrine neoplasia type 1 (MEN1) and Cyclin D1 (CCND1) genes, occur in <50% of nonhereditary (sporadic) parathyroid adenomas.
|
22855342 |
2012 |
|
Parathyroid Adenoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Parathyroid adenomas can contain clonal rearrangements of chromosome 11 that activate the cyclin D1 oncogene through juxtaposition with the PTH gene.
|
20641034 |
2010 |
|
Parathyroid Adenoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Cyclin D1 gene (CCND1) translocation and oncogene action occur in 8% of adenomas; cyclin D1 overexpression is seen in 20% to 40% of parathyroid adenomas and in 31% of secondary hyperplastic glands.
|
19373510 |
2009 |
|
Parathyroid Adenoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This genetic change is essentially limited to parathyroid adenomas (8%), although expression of CCND1 without translocation is common in uremic hyperparathyroidism.
|
18398822 |
2008 |
|
Parathyroid Adenoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of cyclin D1, a key regulator of the cell cycle, has been implicated in the pathogenesis of 20-40% of sporadic parathyroid adenomas.
|
12412775 |
2002 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicate that cyclin D1 is frequently accumulated in parathyroid adenomas, independently of dysfunction in the Wnt signaling pathway.
|
11836555 |
2002 |
|
Parathyroid Adenoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Deletion of 11q23 and cyclin D1 overexpression are frequent aberrations in parathyroid adenomas.
|
11290553 |
2001 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
It has been shown that the multiple endocrine neoplasia tumor suppressor gene (MEN1) is mutated in parathyroid adenomas, and overexpression of the cyclin D1 oncogene [PRAD1 (parathyroid adenoma 1)] seems to contribute to parathyroid tumorigenesis.
|
11167122 |
2001 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A subset of parathyroid adenomas contains a clonal rearrangement that places the PTH gene's regulatory sequences in proximity to the cyclin D1 Oncogene causing its overexpression, and 20-40% of parathyroid adenomas overexpress the cyclin D1 protein.
|
10704427 |
2000 |
|
Parathyroid Adenoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We studied cyclin D1 expression in 65 parathyroid adenomas (from 64 patients), 51 normal parathyroid glands (from the same patients), and 4 parathyroid carcinoma specimens (from 3 patients) using a microwave-enhanced immunohistochemical method and affinity-purified cyclin D1 polyclonal antiserum.
|
8626826 |
1996 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Rearrangement and overexpression of the PRAD1/cyclin D1 oncogene, a cell cycle regulator, have been implicated in the pathogenesis of a subset of parathyroid adenomas.
|
8855819 |
1996 |
|
Parathyroid Adenoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Using single-strand conformational polymorphism (SSCP) analysis, we have examined the coding region of the PRAD1 gene in 30 primary breast cancers and 25 parathyroid adenomas.
|
7621424 |
1995 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CYCLIN D1, a cell-cycle control gene, recently has been shown to be identical to an oncogene alternatively known as BCL-1 and PRAD1 and implicated in centrocytic lymphomas and parathyroid adenomas, respectively.
|
7812927 |
1995 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cyclin D1, an oncogene that has a critical role in G1 progression of the cell cycle, has been observed to be amplified in carcinomas of the breast and head and neck, and translocated in parathyroid adenomas and centrocytic lymphomas.
|
8625145 |
1995 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cyclin D1/PRAD1 is a likely "driver" gene for this amplicon because of its role in cell cycle control and because it has been specifically implicated as an oncogene in parathyroid adenomas and B-cell lymphomas with 11q13 translocation breakpoints.
|
7675778 |
1995 |
|
Parathyroid Adenoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of cyclin D1 is observed in mammary carcinomas as a result of gene amplification and in parathyroid adenomas and centrocytic B-cell lymphomas as a consequence of chromosomal rearrangements and juxtaposition of the cyclin D1 gene to strong transcriptional control elements.
|
8302597 |
1994 |
|
Parathyroid Adenoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Two cell cycle regulators have been implicated in the pathogenesis of parathyroid neoplasms: rearrangement/overexpression of the PRAD1/cyclin D1 gene in parathyroid adenomas and inactivation of the retinoblastoma tumor suppressor gene in parathyroid carcinomas.
|
8200932 |
1994 |
|
Parathyroid Adenoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We also report the sequence of DNAs spanning joining regions of a reciprocal parathyroid hormone/PRAD1 gene rearrangement in a parathyroid adenoma.
|
7687458 |
1993 |
|
Parathyroid Adenoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have sequenced the coding region of the overexpressed PRAD1 transcript from two primary tumors with clonal PRAD1 region rearrangements: a benign parathyroid adenoma and a malignant centrocytic lymphoma.
|
8426754 |
1993 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The human cyclin D1 gene, also known as PRAD1 (and previously as D11S287), is a putative proto-oncogene strongly implicated in several types of human tumors, including parathyroid adenomas, B-cell neoplasms (as the 'BCL-1 oncogene'), and breast and squamous cell cancers.
|
8453274 |
1993 |
|
Parathyroid Adenoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The proto-oncogene PRAD1 (parathyroid adenoma 1) on chromosome 11q13 was found to be overexpressed in all five B-cell lines with t(11;14)(q13;q32) translocation tested.
|
1535701 |
1992 |