RBP4, retinol binding protein 4, 5950

N. diseases: 217; N. variants: 15
Disease: Impaired glucose tolerance ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 GeneticVariation phenotype BEFREE Elevated serum levels of RBP4 were associated with increased risk of IR and might be useful in identifying RA at risk for IR and/or impaired glucose tolerance for early prevention strategies, especially in obese and women patients. 30025962 2019
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 Biomarker phenotype BEFREE Fasting plasma levels of glycated hemoglobin, leptin, pro-insulin and retinol binding protein 4 differed between impaired fasting glucose/impaired glucose tolerance and normal subjects group and between newly detected diabetes and normal subjects group. 29610560 2018
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 Biomarker phenotype BEFREE Because RBP4 is elevated in obesity and associates with the development of glucose intolerance and insulin resistance, we tested whether a liver-specific overexpression of RBP4 in mice impairs glucose homeostasis. 30126844 2018
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 Biomarker phenotype BEFREE RBP4 is produced mainly by hepatocytes.In type 2 diabetes and obesity, circulating RBP4 is increased and may act systemically to cause insulin resistance and glucose intolerance. 27797907 2017
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 AlteredExpression phenotype BEFREE Adjustment for study group, age, BMI, waist circumference, 2 H plasma glucose, triglycerides, gamma glutamyl transferase, and insulin resistance weakened the significance of its association (OR [95%CI]: 1.65 [1.03-2.66]; P = 0.038).The results of this preliminary analyses showed that baseline serum RBP4 levels were independently associated with incident diabetes in Asian Indian men with IGT. 25810022 2015
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 AlteredExpression phenotype BEFREE Transfer of RBP4-activated APCs into normal mice is sufficient to induce AT inflammation, insulin resistance, and glucose intolerance. 24606904 2014
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 Biomarker phenotype BEFREE Prospective studies investigating the impact of RBP4 on the development of glucose intolerance are needed. 21617096 2011
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 Biomarker phenotype BEFREE Plasma RBP4 was significantly elevated in impaired glucose tolerance/T2DM compared with NGT lean or obese subjects. 19190263 2009
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 Biomarker phenotype LHGDN DESIGN, SETTING, PATIENTS, AND MAIN OUTCOME MEASURES: We measured the plasma concentrations of retinol-binding protein-4 (RBP4), transthyretin (TTR), and adiponectin and metabolic parameters in four groups of women who exhibited normal glucose tolerance (NGT) during a previous pregnancy (NP, n = 17), NGT after GDM (GDM-NGT, n = 72), impaired glucose tolerance after GDM (GDM-IGT, n = 60), and type 2 diabetes after GDM (GDM-DM, n = 8). 18492757 2008
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 AlteredExpression phenotype BEFREE RBP4 mRNA levels in adipose tissue and muscle of nondiabetic human subjects with either normal or impaired glucose tolerance (IGT) were studied, along with plasma RBP4. 17595259 2007
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 AlteredExpression phenotype BEFREE Vis fat RBP4 mRNA was increased approximately 60-fold and 12-fold in Vis and SC obese subjects respectively versus lean subjects, and approximately 2-fold with impaired glucose tolerance/T2D subjects versus normoglycemic subjects. 17618858 2007