|
Metabolic Syndrome X
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Conclusions:</b> RBP4 is associated with increased risk for prediabetes and MetS in obese patients with NAFLD.
|
31588816 |
2019 |
|
Metabolic Syndrome X
|
0.100 |
Biomarker
|
disease |
BEFREE |
High retinol-binding protein-4 (RBP-4) and low cholesterol efflux in MetS may provide evidence of possible synergism and elevated atherosclerotic risk.
|
30835048 |
2019 |
|
Metabolic Syndrome X
|
0.100 |
Biomarker
|
disease |
BEFREE |
Notably, RBP4 and retinol were elevated in subjects with metabolic syndrome (<i>p</i> < 0.05), which was attributable to an association with elevated triglycerides (<i>p</i> = 0.013).
|
31717719 |
2019 |
|
Metabolic Syndrome X
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Significant improvements were seen for the net reclassification improvement and integrated discrimination index after adding childhood RBP4 levels into the risk models using conventional cardiometabolic risk factors in predicting MS at follow-up (P < 0.05).
|
29759068 |
2018 |
|
Metabolic Syndrome X
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our study revealed a strong relationship between components of MS and RBP4 in both sexes: plasma RBP4 levels were increased in men by at least 3×, and in women by at least 4×.
|
29524177 |
2018 |
|
Metabolic Syndrome X
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The association of WC and the number of abnormal MetS components with the serum RBP4 level was enhanced by higher HOMA-IR (β for interaction, 0.13 and 0.01 for HOMA1-IR, and 0.32 and 0.02 for HOMA2-IR, respectively).
|
29383816 |
2018 |
|
Metabolic Syndrome X
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The purpose of this study is to evaluate the association between serum levels of RBP4 and MS components in first-degree relations of type 2 diabetic patients.
|
28413425 |
2017 |
|
Metabolic Syndrome X
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recent data suggest that retinol-binding protein 4 (RBP4) gene variants could be associated with a risk of obesity and its co-morbidities, such as metabolic syndrome, which increases the risk of developing type 2 diabetes mellitus and cardiovascular disease.
|
26611784 |
2016 |
|
Metabolic Syndrome X
|
0.100 |
Biomarker
|
disease |
BEFREE |
Elevated RBP4 is associated with the morbidity of cholesterol gallstones and metabolic syndrome.
|
23420326 |
2013 |
|
Metabolic Syndrome X
|
0.100 |
Biomarker
|
disease |
BEFREE |
All three biomarkers exhibited sexual dimorphisms (levels higher in women for fetuin-A and FABP4 but greater in men for RBP4) and were associated positively with insulin resistance assessed using the homeostasis model, with high-sensitivity C-reactive protein, and with prevalent MetSyn (P<0.01 for all).
|
22855337 |
2012 |
|
Metabolic Syndrome X
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The influences of PPARγ (C1431T and Pro12Ala) and RBP4 (-803GA) polymorphisms on metabolic syndrome in HIV-infected patients receiving anti-retroviral therapy were examined in this study.
|
23145084 |
2012 |
|
Metabolic Syndrome X
|
0.100 |
Biomarker
|
disease |
BEFREE |
RBP4 has been associated with insulin resistance and hypertriglyceridemia in obesity, the metabolic syndrome and type 2 diabetes.
|
19765959 |
2010 |
|
Metabolic Syndrome X
|
0.100 |
Biomarker
|
disease |
BEFREE |
With this study, we wanted to investigate the effect of pioglitazone (PIO) and simvastatin (SIMVA) on insulin resistance and RBP4 plasma concentrations in nondiabetic patients with metabolic syndrome and increased risk for cardiovascular complications.
|
19224430 |
2009 |
|
Metabolic Syndrome X
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
No differences were found in RBP4 mRNA expression in the two fat depots or in RBP4 plasma levels between subgroups of non-obese subjects (n=26), obese subjects without metabolic syndrome (n=17) and with metabolic syndrome (n=16).
|
18052678 |
2008 |
|
Metabolic Syndrome X
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the highest RBP4 quartile, the MetS risk was significantly higher (odds ratio 2.58; 95% confidence interval 2.08-3.20) than in the lowest quartile after adjustment for potential confounders.
|
17878249 |
2007 |
|
Metabolic Syndrome X
|
0.100 |
Biomarker
|
disease |
BEFREE |
Elevated serum RBP4 was associated with components of the metabolic syndrome, including increased body-mass index, waist-to-hip ratio, serum triglyceride levels, and systolic blood pressure and decreased high-density lipoprotein cholesterol levels.
|
16775236 |
2006 |