|
Myocardial Infarction
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Besides, the protein levels of SIRT1 and Bcl-2 in myocardial tissues in miR group were remarkably lower than those of M group and MI group (p<0.05).
|
31486508 |
2019 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, overexpressing miR-203 greatly improved the cardiac function, reduced infarct size in rats after MI and weakened infarction-induced apoptosis by increasing Bcl-2 and reducing decreasing Bax, cleaved caspase-3, and cleaved caspase-9.
|
31725080 |
2019 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
The expression of heat shock protein 60 (HSP60), a direct target of miR‑1, was identified to be decreased in MI and H2O2‑induced apoptosis, which was associated with a decrease in Bcl‑2 and an increase in Bax; expression was restored following treatment with carvedilol.
|
30896796 |
2019 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
These inflammatory biomarkers decreased in MI-C. Also, apoptotic proteins (Bax and pBad) were elevated in MI-V, while clofibrate augmented anti-apoptotic proteins (Bcl-2 and 14-3-3ε).
|
30642049 |
2019 |
|
Myocardial Infarction
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This study examined the effects of aliskiren (Ali) (direct renin inhibitor) on serum cardiac enzymes (LDH and CK-MB), electrocardiography (ECG) changes, myocardial oxidative stress markers (MDA, CAT, and GSH) and the expression of Bcl2, HO-1, and Nrf2 genes in isoproterenol (ISO)-induced myocardial infarction (MI).
|
29975120 |
2018 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the present study, diabetes complicated by MI promoted ST-segment elevation and myocardial apoptosis, increased infarct size, induced pathological changes and elevated LVEDP, CK-MB, cTnT, GRP78, CHOP, Bax, Ero1α, Ero1β and PDI; however, it decreased heart rate, LVSP and Bcl-2.
|
29725368 |
2018 |
|
Myocardial Infarction
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Compared with the I/R group, S-post significantly increased the expression of p-JAK, p-STAT3 and Bcl-2 and reduced the protein expression of Bax, which markedly decreased the myocardial infarction areas, improved the cardiac function indicators and the mitochondrial ultrastructure, decreased the mitochondrial ROS and increased the ATP content.
|
28392989 |
2017 |
|
Myocardial Infarction
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The nRIC group repeatedly underwent 5 min of ischemia and 5 min of reperfusion in the left hind limb for three cycles every other day until weeks 4, 6, and 8 after MI. nRIC improved cardiac hemodynamic function and mitochondrial respiratory function through increasing myocardial levels of mitochondrial respiratory chain complexes I, II, III, IV, and adenosine triphosphate (ATP) and decreasing the activity of nitric oxide synthase (NOS). nRIC could inhibit cardiomyocytes apoptosis and reduce myocardium injury through raising the expression of Bcl-2 and reduced the content of creatine kinase-MB, cardiac troponin I and Bax.
|
28479248 |
2017 |
|
Myocardial Infarction
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
<i>In vivo</i>, the MI mice exhibited worse cardiac function by echocardiographic assessment and showed larger myocardial scarring by light microscopy, whereas aliskiren treatment reversed these effects, which were also associated with the changes in caspase-3 and Bcl-2 expression as well as in the number of apoptotic cells.
|
29184499 |
2017 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, the histopathological investigations in the heart tissue of ISO-induced group exhibited myocardial necrosis and inflammation, which correlated with the increased immunoreactivity for Bax/iNOS, whereas an absence of reactivity for Bcl-2 proteins.
|
28249249 |
2017 |
|
Myocardial Infarction
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Western blot analysis showed increased VEGF, Ang-1 & Bcl-2 expression in PHD3⁻/⁻MI group.
|
23978105 |
2014 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
CTD_human |
Following the improvement of cardiac function and ventricular remodeling, ICER and CREB mRNA in pre- and post- myocardial-infarction groups were down-regulated, and phosphodiesterase 3A and Bcl-2 mRNA were up-regulated (P<0.05).
|
19027736 |
2009 |