|
Lymphoma, Large-Cell, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Follicular lymphoma (FL) is the most common indolent B-cell non-Hodgkin lymphoma (NHL) with genetic alterations of BCL-2, KMT2B, and KMT6.
|
30693983 |
2019 |
|
Lymphoma, Large-Cell, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
DNA was extracted from archival CPs of B-cell NHL cases with previous fluorescence in situ hybridization (FISH) assays for MYC rearrangement and/or IGH/BCL-2 translocation.
|
25807917 |
2015 |
|
Lymphoma, Large-Cell, Follicular
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Follicular lymphoma grade 3 was correlated with nodal disease and negative or lower intensity of Bcl-2 expression, but not with age, stage, or IGH/BCL2 status.
|
23916290 |
2013 |
|
Lymphoma, Large-Cell, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
This indicates that primers for bcl-2 gene must include icr primer, whenever the bcl-2 gene is being evaluated for B-cell NHL in this part of the world and this might reduce the variability of frequency of bcl-2 gene rearrangement within and between different regions.
|
19537891 |
2009 |
|
Lymphoma, Large-Cell, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to analyze the bcl-2/IgH rearrangement in FL lymphoma patients in Serbia, by PCR technique, correlate molecular findings with clinical characteristics and outcome and assess the prognostic significance of these rearrangements.
|
18665753 |
2008 |
|
Lymphoma, Large-Cell, Follicular
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Diffuse large B-cell lymphoma and follicular lymphoma grade 3 with >75% follicular growth pattern patients have very similar characteristics and their prognosis is more influenced by protein expression of B-cell differentiation stage genes than by tumor cells growth pattern, BCL2 and BCL6 abnormalities, and International Prognostic Index.
|
18925696 |
2008 |
|
Lymphoma, Large-Cell, Follicular
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Some evidence suggests that IL-10 might be associated with the progression of T-cell NHLs and that IL-10 may be involved in a rescue effect, protecting T cells from apoptotic cell death associated with upregulated bcl-2 expression.
|
17408400 |
2007 |
|
Lymphoma, Large-Cell, Follicular
|
0.400 |
Biomarker
|
disease |
CTD_human |
High molecular response rate and clinical correlation in patients with follicular lymphoma treated with cyclophosphamide-vincristine-prednisone plus interferon alpha 2b.
|
12855623 |
2003 |
|
Lymphoma, Large-Cell, Follicular
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We conclude that neither the absence of the t(14;18) nor the lack of bcl2 expression explain the good response of a subset of patients with FLCL to curative therapy.
|
10784396 |
2000 |
|
Lymphoma, Large-Cell, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
NHL is commoner in men than in women, and our data indicate a trend toward higher bcl2 mutagenesis in males than females.
|
9020305 |
1997 |
|
Lymphoma, Large-Cell, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
The first member of this gene family to be identified was BCL-2, by virtue of its involvement in t(14;18) chromosomal translocations commonly found in B-cell non-Hodgkin's lymphoma (NHL).
|
9408956 |
1997 |
|
Lymphoma, Large-Cell, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
Among lymphomas, IgH monoclonality was detected in 7 (77%) of 9 NHLs and BCL2 rearrangement in 3 (17.6%) of 17 NHLs, all of which were follicular centroblastic-centrocytic (FCBCC).
|
9276187 |
1997 |
|
Lymphoma, Large-Cell, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, in another series of 11 patients and a NHL cell line, we demonstrated t(14;18) and t(11;14) in interphase and metaphase cells with a combination of BCL2 (or PRAD1) with IgH gene probes.
|
9209369 |
1997 |
|
Lymphoma, Large-Cell, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
We conclude that bcl-2 gene deregulation, but not the precise moment at which this occurs during the pre-B-cell stage, influences the development of follicular NHL.
|
8555066 |
1995 |
|
Lymphoma, Large-Cell, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
Meanwhile, 11 cases of follicular large cell lymphoma revealed no bcl-2-JH fusion gene.
|
8449825 |
1993 |
|
Lymphoma, Large-Cell, Follicular
|
0.400 |
Biomarker
|
disease |
CTD_human |
Expression in non-Hodgkin's lymphoma of the bcl-2 protein associated with the t(14;18) chromosomal translocation.
|
3287162 |
1988 |